Strategies for intranasal delivery of vaccines

Zaman, Mehfuz, Chandrudu, Saranya and Toth, Istvan (2013) Strategies for intranasal delivery of vaccines. Drug Delivery and Translational Research, 39 1: 100-109. doi:10.1007/s13346-012-0085-z

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Author Zaman, Mehfuz
Chandrudu, Saranya
Toth, Istvan
Title Strategies for intranasal delivery of vaccines
Journal name Drug Delivery and Translational Research   Check publisher's open access policy
ISSN 2190-393X
2190-3948
Publication date 2013-02
Year available 2012
Sub-type Article (original research)
DOI 10.1007/s13346-012-0085-z
Volume 39
Issue 1
Start page 100
End page 109
Total pages 10
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2013
Language eng
Abstract The vast majority of human pathogens colonize and invade at the mucosal surfaces. Preventing infection at these sites via mucosally active vaccines is a promising and rational approach for vaccine development. However, it is only recently that the stimulation of local immunity at the mucosal surfaces has become a primary objective in addition to inducing systemic immunity. This review describes vaccine formulations designed for mucosal delivery to the nasal-associated lymphoid tissue, via intranasal administration. The association of antigens with mucosal adjuvants and delivery systems is emphasised.
Keyword Mucosal adjuvant
Nasal vaccine
Immunity
Vaccine delivery
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 12 July 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Chemistry and Molecular Biosciences
School of Pharmacy Publications
 
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Created: Fri, 18 Jan 2013, 13:55:59 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences