Prediction of body water compartments in preterm infants by bioelectrical impedance spectroscopy

Collins, C. T., Reid, J., Makrides, M., Lingwood, B. E., McPhee, A. J., Morris, S. A., Gibson, R. A. and Ward, L. C. (2013) Prediction of body water compartments in preterm infants by bioelectrical impedance spectroscopy. European Journal of Clinical Nutrition, 67 Supp S1: S47-S53. doi:10.1038/ejcn.2012.164


Author Collins, C. T.
Reid, J.
Makrides, M.
Lingwood, B. E.
McPhee, A. J.
Morris, S. A.
Gibson, R. A.
Ward, L. C.
Title Prediction of body water compartments in preterm infants by bioelectrical impedance spectroscopy
Journal name European Journal of Clinical Nutrition   Check publisher's open access policy
ISSN 0954-3007
1476-5640
Publication date 2013-01
Sub-type Article (original research)
DOI 10.1038/ejcn.2012.164
Volume 67
Issue Supp S1
Start page S47
End page S53
Total pages 7
Place of publication London, United Kingdom
Publisher Nature
Collection year 2014
Language eng
Formatted abstract
Background/Objectives: To evaluate nutritional interventions in preterm infants, a simple, accurate assessment of the type of growth, that is, change in body composition through the relative contributions of lean body tissue and fat mass to weight gain, is needed. Bioelectrical impedance may provide such a method. The aim of this study was to develop resistivity coefficients appropriate for use in bioelectrical impedance spectroscopy (BIS) analysis of body water volumes in preterm infants.

Subjects/Methods: A total of 99 preterm infants were enrolled (mean gestational age 32 completed weeks). Total body water (TBW) and extracellular water (ECW) were determined using the reference methods of deuterium and bromide dilution. BIS measurements taken at the same time allowed calculation of resistivity coefficients. Predictions of TBW and ECW obtained using these coefficients were then validated against volumes determined using the reference methods in a separate cohort of infants.

Results: Data were available for 91 preterm infants. BIS-predicted TBW and ECW correlated well with the measured volumes (Pearson’s rp=0.825 and 0.75, respectively). There was a small bias (TBW 10 ml and ECW 40 ml) but large limits of agreement (TBW±650 ml and ECW ±360 ml).

Conclusions: BIS appears to have limited clinical utility; however, the relatively small bias means that it may be useful for measurements within a population or for comparisons between groups in which population means rather than individual values are compared.
Keyword Body composition
Electrical impedance
Body water
Infant newborn
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
School of Chemistry and Molecular Biosciences
 
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Created: Fri, 18 Jan 2013, 13:40:22 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences