Pseudoephedrine and pre-exercise feeding: influence on performance

Pritchard-Peschek, Kellie R., Osborne, Mark A., Slater, Gary J., Taaffe, Dennis R. and Jenkins, David G. (2013) Pseudoephedrine and pre-exercise feeding: influence on performance. Medicine and Science in Sports and Exercise, 45 6: 1152-1157. doi:10.1249/MSS.0b013e3182808e23

Author Pritchard-Peschek, Kellie R.
Osborne, Mark A.
Slater, Gary J.
Taaffe, Dennis R.
Jenkins, David G.
Title Pseudoephedrine and pre-exercise feeding: influence on performance
Journal name Medicine and Science in Sports and Exercise   Check publisher's open access policy
ISSN 0195-9131
Publication date 2013-06
Year available 2012
Sub-type Article (original research)
DOI 10.1249/MSS.0b013e3182808e23
Volume 45
Issue 6
Start page 1152
End page 1157
Total pages 6
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Collection year 2013
Language eng
Formatted abstract
Purpose: This study examined the influence of pre-exercise food intake on plasma PSE concentrations and subsequent high intensity exercise. Additionally, urinary PSE concentrations were measured under the same conditions and compared to the present WADA threshold.

Methods: Ten highly trained male cyclists and triathletes (age 30.6 ± 6.6 years, body mass 72.9 ± 5.1 kg, O2max 64.8 ± 4.5 ml·kgmin) undertook four cycling time trials (TTs) each requiring the completion of a set amount of work (7 kJ·kg BM) in the shortest possible time. Participants were randomized into a fed or non-fed condition and orally ingested 2.8 mg·kg BM of PSE or a placebo (PLA) 90 min before exercise; in the fed trials, they consumed a meal providing 1.5 g·kg BM of carbohydrate. Venous blood was sampled at 30, 50, 70 min and pre-warm up and post-exercise for the analysis of plasma PSE and catecholamine concentrations, urine was also collected for the analysis of PSE concentration.

Results: Independent of the pre-exercise meal, 2.8 mg·kg BM of PSE did not significantly improve cycling TT performance. The fed trials resulted in lower plasma PSE concentrations at all time points compared to the non-fed trials. Both plasma epinephrine and blood lactate concentrations were higher in the PSE compared to the placebo trials and pre- and post-exercise urinary PSE concentrations were significantly higher than the threshold (150 μg·mL) used by WADA to determine illicit PSE use.

Conclusions: Irrespective of the pre-exercise meal, cycling TT performance of ~30 min was not improved following PSE supplementation. Furthermore, 2.8 mg·kg BM of PSE taken 90 min before exercise, with or without food, resulted in urinary PSE concentrations exceeding the present WADA threshold.
Keyword Ergogenic aid
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Human Movement and Nutrition Sciences Publications
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Created: Fri, 18 Jan 2013, 11:05:57 EST by Deborah Noon on behalf of School of Human Movement and Nutrition Sciences