Growth hormone and cell growth

Waters, Michael J. and Brooks, Andrew J. (2012). Growth hormone and cell growth. In: P.-E. Mullis, Developmental biology of GH secretion, growth and treatment. 6th ESPE Advanced Seminar in Developmental Endocrinology, Bern, Switzerland, (86-95). 10-11 May 2012. doi:10.1159/000341761

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Author Waters, Michael J.
Brooks, Andrew J.
Title of paper Growth hormone and cell growth
Conference name 6th ESPE Advanced Seminar in Developmental Endocrinology
Conference location Bern, Switzerland
Conference dates 10-11 May 2012
Proceedings title Developmental biology of GH secretion, growth and treatment   Check publisher's open access policy
Journal name Endocrine Development   Check publisher's open access policy
Series Endocrine Development
Place of Publication Basel, Switzerland
Publisher S. Karger
Publication Year 2012
Sub-type Fully published paper
DOI 10.1159/000341761
ISBN 9783318022445
9783318022452
ISSN 1421-7082
1662-2979
Editor P.-E. Mullis
Volume 23
Start page 86
End page 95
Total pages 10
Collection year 2013
Language eng
Abstract/Summary Growth hormone (GH) promotes stem cell activation, cell proliferation, differentiation and survival, either directly or through the induction of IGF-1. GH acts via its cell membrane receptor to initiate a range of signalling pathways, with JAK2 kinase activation of STAT5 being the most important. The transcription factor STAT5 acts to induce expression of the key growth mediator, IGF-1, but also regulates the expression of a host of other genes, some of which are important growth regulators. In addition to its signalling from the cell membrane, the GH receptor translocates to the nucleus in a GH-dependent manner, where it regulates the expression of other cell growth-related genes, and sensitises the cell to the proliferative action of GH.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 17 Jan 2013, 13:58:07 EST by Susan Allen on behalf of Institute for Molecular Bioscience