Enhanced uptake of nanoparticle drug carriers via a thermoresponsive shell enhances cytotoxicity in a cancer cell line

Abulateefeh, Samer R., Spain, Sebastian G., Thurecht, Kristofer J., Aylott, Jonathan W., Chan, Weng C., Garnett, Martin C. and Alexander, Cameron (2013) Enhanced uptake of nanoparticle drug carriers via a thermoresponsive shell enhances cytotoxicity in a cancer cell line. Biomaterials Science, 1 4: 434-442. doi:10.1039/c2bm00184e

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Author Abulateefeh, Samer R.
Spain, Sebastian G.
Thurecht, Kristofer J.
Aylott, Jonathan W.
Chan, Weng C.
Garnett, Martin C.
Alexander, Cameron
Title Enhanced uptake of nanoparticle drug carriers via a thermoresponsive shell enhances cytotoxicity in a cancer cell line
Journal name Biomaterials Science   Check publisher's open access policy
ISSN 2047-4830
2047-4849
Publication date 2013-04-01
Year available 2013
Sub-type Article (original research)
DOI 10.1039/c2bm00184e
Open Access Status DOI
Volume 1
Issue 4
Start page 434
End page 442
Total pages 9
Place of publication Cambridge, United Kingdom
Publisher R S C Publications
Collection year 2014
Language eng
Abstract Polymer particles consisting of a biodegradable poly[lactide-co-glycolide] (PLGA) core and a thermoresponsive shell have been formulated to encapsulate the dye rhodamine 6G and the potent cytotoxic drug paclitaxel. Cellular uptake of these particles is significantly enhanced above the thermal transition temperature (TTT) of the polymer shells in the human breast carcinoma cell line MCF-7 as determined by flow cytometry and fluorescence microscopy. Paclitaxel-loaded particles display reduced and enhanced cytotoxicity below and above the TTT respectively compared to unencapsulated drug. The data suggests a potential route to enhanced anti-cancer efficacy through temperature-mediated cell targeting.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Wed, 16 Jan 2013, 13:18:59 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging