In vivo trial results of a novel ultrasonic cough stimulator

Nitz, Jennifer C., Perrier, John and Cook, Peter (2012) In vivo trial results of a novel ultrasonic cough stimulator. Jounal of Rehabilitation Research and Development, 49 9: 1421-1430. doi:10.1682/JRRD.2011.07.0121

Author Nitz, Jennifer C.
Perrier, John
Cook, Peter
Title In vivo trial results of a novel ultrasonic cough stimulator
Journal name Jounal of Rehabilitation Research and Development   Check publisher's open access policy
ISSN 0748-7711
Publication date 2012
Sub-type Article (original research)
DOI 10.1682/JRRD.2011.07.0121
Open Access Status DOI
Volume 49
Issue 9
Start page 1421
End page 1430
Total pages 10
Place of publication Baltimore, United States
Publisher Department of Veterans Affairs, Veterans Health Administration
Collection year 2013
Language eng
Abstract The aims of these double-blind in-vivo trials of a prototype ultrasonic cough stimulator (CoughStim™) were to establish (1) whether ultrasound (US) stimulation can be safely used to stimulate a cough, (2) the most efficient US frequency and power parameters to reliably stimulate a cough, (3) whethersingle- or dual-sided stimulation is more effective, and (4) whethera cough can be stimulated in adults unable to cough on demand.Fifteen nondisabled volunteers (18–59 yr) and seven volunteers unable to cough on demand (85–102 yr) were recruited. Stimulation was applied to the neck unilaterally at eight frequencies and two power levels and bilaterally at two frequencies and three power levels. Vital signs were monitored during testing with no adverse responses. CoughStim stimulated a cough in all nondisabled subjects, 80% of subjects at 0.58 MHz and 9 W unilaterally and 75% of subjects at 0.58 MHz and 6 W bilaterally. Of the subjects unable to cough, 71 percent responded to bilateral stimuli (0.54 MHz and 6 W) with a strong cough. The CoughStim regularly and safely produced a moderately strong cough response in subjects with or without ability to cough and produced this effect without causing undue discomfort.
Keyword Clinical trial
Cough response
Cough stimulation
Cough strength
In vivo
Secretion removal
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Health and Rehabilitation Sciences Publications
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Created: Wed, 16 Jan 2013, 08:17:19 EST by Jennifer Nitz on behalf of School of Health & Rehabilitation Sciences