Differences in genomic architecture between two distinct geographical strains of the blood fluke Schistosoma japonicum reveal potential phenotype basis

Gobert, Geoffrey N., You, Hong, Jones, Malcolm K., McInnes, Russell and McManus, Donald P. (2013) Differences in genomic architecture between two distinct geographical strains of the blood fluke Schistosoma japonicum reveal potential phenotype basis. Molecular and Cellular Probes, 27 1: 19-27. doi:10.1016/j.mcp.2012.08.005


Author Gobert, Geoffrey N.
You, Hong
Jones, Malcolm K.
McInnes, Russell
McManus, Donald P.
Title Differences in genomic architecture between two distinct geographical strains of the blood fluke Schistosoma japonicum reveal potential phenotype basis
Journal name Molecular and Cellular Probes   Check publisher's open access policy
ISSN 0890-8508
1096-1194
Publication date 2013-02
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.mcp.2012.08.005
Open Access Status
Volume 27
Issue 1
Start page 19
End page 27
Total pages 9
Place of publication London, United Kingdom
Publisher Academic Press
Collection year 2013
Language eng
Abstract The Chinese (SjC) and Philippine (SjP) strains of the blood fluke Schistosoma japonicum have been shown to present clearly different phenotypes in fecundity, pathology, drug sensitivity and immunology. We used microarray based comparative genomic hybridisation (aCGH) to investigate structural differences in the genomes of the two strains and identified seven distinct regions of the S. japonicum genome that present differential aCGH representing either deletion or duplication regions in SjP. Within these regions, genes predicted to be associated with the recognised phenotypic differences were identified and that may provide new insights into the biology and evolution of the two strains, with implications for the epidemiology and control of schistosomiasis japonica in China and the Philippines.
Keyword Microarray
Schistosoma
Comparative genomics
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online: 28 August 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Veterinary Science Publications
 
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