Complement in pregnancy: a delicate balance

Denny, Kerina J., Woodruff, Trent M., Taylor, Stephen M. and Callaway, Leonie K. (2013) Complement in pregnancy: a delicate balance. American Journal of Reproductive Immunology, 69 1: 3-11. doi:10.1111/aji.12000


Author Denny, Kerina J.
Woodruff, Trent M.
Taylor, Stephen M.
Callaway, Leonie K.
Title Complement in pregnancy: a delicate balance
Journal name American Journal of Reproductive Immunology   Check publisher's open access policy
ISSN 1046-7408
1600-0897
Publication date 2013-01
Year available 2012
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/aji.12000
Volume 69
Issue 1
Start page 3
End page 11
Total pages 9
Place of publication Malden, MA, United States
Publisher Wiley-Blackwell
Collection year 2013
Language eng
Formatted abstract
The complement system is a key component of innate host defence that, under normal conditions, is responsible for the opsonization and destruction of potential pathogens. However, inappropriate or excessive activation of complement can have a detrimental effect on the host and has been implicated in the pathophysiology of numerous disease states. Recently, there has been increasing evidence for a role of the complement system and, in particular, the potent pro-inflammatory anaphylatoxin complement component 5a (C5a) in both normal and complicated pregnancy. The following review describes the results of in vitro, animal, and human clinical studies investigating the role of the complement system in healthy pregnancy, recurrent miscarriage, preterm birth, and preeclampsia.
Keyword C5a
Preeclampsia
Preterm birth
Recurrent miscarriage
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 27 August 2012

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
ERA White List Items
School of Biomedical Sciences Publications
School of Medicine Publications
 
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