Liposome-based delivery system for vaccine candidates: constructing an effective formulation

Giddam, Ashwin Kumar, Zaman, Mehfuz, Skwarczynski, Mariusz and Toth, Istvan (2012) Liposome-based delivery system for vaccine candidates: constructing an effective formulation. Nanomedicine, 7 12: 1877-1893. doi:10.2217/nnm.12.157

Author Giddam, Ashwin Kumar
Zaman, Mehfuz
Skwarczynski, Mariusz
Toth, Istvan
Title Liposome-based delivery system for vaccine candidates: constructing an effective formulation
Journal name Nanomedicine   Check publisher's open access policy
ISSN 1743-5889
Publication date 2012-12
Year available 2012
Sub-type Article (original research)
DOI 10.2217/nnm.12.157
Volume 7
Issue 12
Start page 1877
End page 1893
Total pages 17
Place of publication London, United Kingdom
Publisher Future Medicine
Collection year 2013
Language eng
Abstract The discovery of liposomes in 1965 by Bangham and coworkers changed the prospects of drug delivery systems. Since then, the application of liposomes as vaccine delivery systems has been studied extensively. Liposomal vaccine delivery systems are made up of nano- or micro-sized vesicles consisting of phospholipid bilayers, in which the bioactive molecule is encapsulated/ entrapped, adsorbed or surface coupled. In general, liposomes are not immunogenic on their own; thus, liposomes combined with immunostimulating ligands (adjuvants) or various other formulations have been used as vaccine delivery systems. A thorough understanding of formulation parameters allows the design of effective liposomal vaccine delivery systems. This article provides an overview of various factors that influence liposomal immunogenicity. In particular, the effects of vesicle size, surface charge, bilayer composition, lamellarity, pegylation and targeting of liposomes are described.
Keyword Adjuvant
Delivery system
Vesicle size
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Chemistry and Molecular Biosciences
School of Pharmacy Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 22 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 25 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 11 Jan 2013, 13:53:02 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences