Zinc combined with vitamin A reduces upper respiratory tract infection morbidity in a randomised trial in preschool children in Indonesia

Kartasurya, Martha I., Ahmed, Faruk, Subagio, Hertanto W., Rahfiludin, Muhammad Z. and Marks, Geoffrey C. (2012) Zinc combined with vitamin A reduces upper respiratory tract infection morbidity in a randomised trial in preschool children in Indonesia. British Journal of Nutrition, 108 12: 2251-2260. doi:10.1017/S0007114512000499


Author Kartasurya, Martha I.
Ahmed, Faruk
Subagio, Hertanto W.
Rahfiludin, Muhammad Z.
Marks, Geoffrey C.
Title Zinc combined with vitamin A reduces upper respiratory tract infection morbidity in a randomised trial in preschool children in Indonesia
Journal name British Journal of Nutrition   Check publisher's open access policy
ISSN 0007-1145
1475-2662
Publication date 2012
Sub-type Article (original research)
DOI 10.1017/S0007114512000499
Volume 108
Issue 12
Start page 2251
End page 2260
Total pages 10
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Collection year 2013
Language eng
Abstract Zn supplementation has shown inconsistent effects on respiratory morbidity in young children in developing countries. Few studies have focused on upper respiratory tract infection (URTI), a frequent cause of morbidity in this group, and potential benefit from Zn supplementation or factors that influence its efficacy. We investigated the effects of Zn supplementation on URTI before and after vitamin A supplementation. This randomised double-blinded controlled Zn supplementation study was conducted on 826 children aged 2–5 years. Placebo or Zn (10 mg/d) was given in syrup daily for 4 months, with 200 000 IU vitamin A (60 mg retinol) given to all children at 2 months. Health workers visited children every 3 d for compliance and morbidity information. We found that 84 % of children experienced URTI during the study. Zn supplementation reduced the percentage of days with URTI (12 % reduction; P = 0·09), with greater impact following vitamin A supplementation (20 % reduction; P = 0·01). Vitamin A supplementation was associated with a decreased number but an increased duration of URTI episodes. We conclude that Zn combined with vitamin A supplementation significantly reduced the percentage of days with URTI in a population of preschool Indonesian children with marginal nutritional status. The results suggest that vitamin A status modifies the efficacy of Zn supplementation on URTI.
Keyword Zinc
Vitamin A
Upper respiratory tract infections
Preschool children
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes First published online: 14 March 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Public Health Publications
 
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Created: Wed, 09 Jan 2013, 14:53:25 EST by Geraldine Fitzgerald on behalf of School of Public Health