A systematic review of two outcomes in autism spectrum disorder - epilepsy and mortality

Woolfenden, Sue, Sarkozy, Vanessa, Ridley, Greta, Coory, Michael and Williams, Katrina (2012) A systematic review of two outcomes in autism spectrum disorder - epilepsy and mortality. Developmental Medicine and Child Neurology, 54 4: 306-312. doi:10.1111/j.1469-8749.2012.04223.x


Author Woolfenden, Sue
Sarkozy, Vanessa
Ridley, Greta
Coory, Michael
Williams, Katrina
Title A systematic review of two outcomes in autism spectrum disorder - epilepsy and mortality
Journal name Developmental Medicine and Child Neurology   Check publisher's open access policy
ISSN 0012-1622
1469-8749
Publication date 2012-04
Sub-type Article (original research)
DOI 10.1111/j.1469-8749.2012.04223.x
Open Access Status
Volume 54
Issue 4
Start page 306
End page 312
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
AIM It has been reported that rates of epilepsy and mortality are higher among the population with autism spectrum disorder (ASD) than in the general population. The aim of this systematic review is to provide comprehensive evidence for clinicians, carers, and people with ASD regarding these outcomes.
METHOD Studies were eligible for inclusion if the main focus of the study involved observation over a period of 12 months or more of an initially defined population (with appropriate diagnostic label). Studies were also required to have at least 30 participants in order to differentiate case series from cohort studies. The Cochrane Database of Systematic Reviews, the Database of Reviews of Effectiveness, MEDLINE, PsycINFO, EMBASE, and CINAHL were searched. The date of the last
search was September 2010. The risk of bias of included studies was assessed and ameta-analysis was undertaken.
RESULTS Twenty-one studies were identified, 16measuring the percentage of participants with epilepsy and fivemeasuring mortality using a standardized mortality ratio. The pooled estimate for the percentage of participants with epilepsy was 1.8% (95% CI 0.4–9.4%) in studies in which the majority did not have an intellectual disability and the mean age was <12 years at follow-up, and 23.7% (95% CI 17.5–30.5%) in studies in which the majority did have an intellectual disability and
themean age at follow-up was more than 12 years. The pooled estimate for the standardized mortality ratio was 2.8 (95% CI 1.8–4.2).
INTERPRETATION The prevalence of epilepsy is higher among the population with ASD than in the general population. People with ASD have a higher risk of mortality than the general population. This has important health promotion implications.
Keyword Pervasive Developmental Disorders
Follow up
Intellectual Disability
Mental Retardation
Young adults
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Public Health Publications
 
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Created: Wed, 09 Jan 2013, 14:33:49 EST by Geraldine Fitzgerald on behalf of School of Public Health