Surgical management in patients with pancreatic cancer: a Queensland perspective

Wylie, Neil, Adib, Reza, Barbour, Andrew P., Fawcett, Jonathan, Hill, Alexander, Lynch, Stephen, Martin, Ian, O'Rourke, Thomas R., Puhalla, Harald, Rutherford, Leigh, Slater, Kellee, Whiteman, David C., Neale, Rachel E. and Queensland Pancreatic Cancer Study Group (2012) Surgical management in patients with pancreatic cancer: a Queensland perspective. ANZ Journal of Surgery, 83 11: 859-864. doi:10.1111/j.1445-2197.2012.06312.x

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Author Wylie, Neil
Adib, Reza
Barbour, Andrew P.
Fawcett, Jonathan
Hill, Alexander
Lynch, Stephen
Martin, Ian
O'Rourke, Thomas R.
Puhalla, Harald
Rutherford, Leigh
Slater, Kellee
Whiteman, David C.
Neale, Rachel E.
Queensland Pancreatic Cancer Study Group
Total Author Count Override 56
Title Surgical management in patients with pancreatic cancer: a Queensland perspective
Journal name ANZ Journal of Surgery   Check publisher's open access policy
ISSN 1445-1433
Publication date 2012-10
Sub-type Article (original research)
DOI 10.1111/j.1445-2197.2012.06312.x
Volume 83
Issue 11
Start page 859
End page 864
Total pages 6
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2013
Language eng
Formatted abstract
Background: Little has been published regarding presenting symptoms, investigations and outcomes for patients with pancreatic cancer in Australia. Data from a series of patients undergoing attempted resection in Queensland, Australia, are presented with the aim of assisting development of consistent strategies in disease management.
Methods: We reviewed the medical records of 121 patients who underwent attempted
surgical resection and who took part in a case-control study between 2007 and 2009.
Information relating to symptoms, investigations, surgical procedures and outcomes
was captured.
: The mean age was 63 years and 60% were men. The most common presenting symptoms were jaundice (64%) and pain (63%). Over 80% of patients had multiple imaging investigations or laparoscopy prior to surgery. Seventy-eight patients (64%) had a completed resection and 23% of these had involved margins. The  presence of metastases and/or involvement of vessels or adjacent structures precluded resection in the remaining patients. The 1-year survival for patients whose resections were completed was 77% compared with 51% for those whose tumours were not resectable (P = 0.004). There was no 30-day mortality and 68% of patients were alive 1 year after diagnosis. Resections were performed in 11 different hospitals but over 90% of patients underwent their surgery in one of five high-volume centres.
Conclusion: The Queensland experience is consistent with that reported internationally. A significant proportion of attempted resections was not completed because preoperative staging underestimated disease extent. Most patients with potentially resectable disease are being treated in high-volume centres.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 24 OCT 2012

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 09 Jan 2013, 09:01:30 EST by Matthew Lamb on behalf of School of Medicine