Salt, aldosterone and hypertension

Pimenta, E., Gordon, R. D. and Stowasser, M. (2013) Salt, aldosterone and hypertension. Journal of Human Hypertension, 27 1: 1-6. doi:10.1038/jhh.2012.27

Author Pimenta, E.
Gordon, R. D.
Stowasser, M.
Title Salt, aldosterone and hypertension
Journal name Journal of Human Hypertension   Check publisher's open access policy
ISSN 0950-9240
Publication date 2013-01
Year available 2012
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/jhh.2012.27
Open Access Status
Volume 27
Issue 1
Start page 1
End page 6
Total pages 6
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2013
Language eng
Abstract Clinical studies have shown that aldosterone and salt are independently related to hypertension, cardiovascular morbidity and mortality. More recently, studies in humans have demonstrated that, similarly to animals, endogenous aldosterone and dietary salt intake have not only separate, but also combined effects to accelerate target-organ deterioration. The aldosterone–salt interaction has important clinical implications, because combined effects of both can be minimized, if not avoided, by reducing salt intake. This interaction could also be interrupted by blocking the effects of aldosterone, with use of mineralocorticoid receptor antagonists, or by reducing aldosterone effects by adrenalectomy, in patients with aldosterone producing adenoma. Furthermore, aldosterone reduction or blockade may reduce salt appetite.
Keyword Hypertension
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 12 July 2012.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
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