A randomised trial of robotic and open prostatectomy in men with localised prostate cancer

Gardiner, Robert A., Yaxley, John, Coughlin, Geoff, Dunglison, Nigel, Occhipinti, Stefano, Younie, Sandra, Carter, Rob, Williams, Scott, Medcraft, Robyn J., Bennett, Nigel, Lavin, Martin F. and Chambers, Suzanne Kathleen (2012) A randomised trial of robotic and open prostatectomy in men with localised prostate cancer. BMC Cancer, 12 189.1-189.6. doi:10.1186/1471-2407-12-189

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Author Gardiner, Robert A.
Yaxley, John
Coughlin, Geoff
Dunglison, Nigel
Occhipinti, Stefano
Younie, Sandra
Carter, Rob
Williams, Scott
Medcraft, Robyn J.
Bennett, Nigel
Lavin, Martin F.
Chambers, Suzanne Kathleen
Title A randomised trial of robotic and open prostatectomy in men with localised prostate cancer
Journal name BMC Cancer   Check publisher's open access policy
ISSN 1471-2407
Publication date 2012-05
Sub-type Article (original research)
DOI 10.1186/1471-2407-12-189
Open Access Status DOI
Volume 12
Start page 189.1
End page 189.6
Total pages 6
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2013
Language eng
Formatted abstract
Background
Prostate cancer is the most common male cancer in the Western world however there is ongoing debate about the optimal treatment strategy for localised disease. While surgery remains the most commonly received treatment for localised disease in Australia more recently a robotic approach has emerged as an alternative to open and laparoscopic surgery. However, high level data is not yet available to support this as a superior approach or to guide treatment decision making between the alternatives. This paper presents the design of a randomised trial of Robotic and Open Prostatectomy for men newly diagnosed with localised prostate cancer that seeks to answer this question.
Methods/design
200 men per treatment arm (400 men in total) are being recruited after diagnosis and before treatment through a major public hospital outpatient clinic and randomised to 1) Robotic Prostatectomy or 2) Open Prostatectomy. All robotic prostatectomies are being performed by one surgeon and all open prostatectomies are being performed by one other surgeon. Outcomes are being measured pre-operatively and at 6 weeks and 3, 6, 12 and 24 months post-surgery. Oncological outcomes are being related to positive surgical margins, biochemical recurrence +/− the need for further treatment. Non-oncological outcome measures include: pain, physical and mental functioning, fatigue, summary (preference-based utility scores) and domain-specific QoL (urinary incontinence, bowel function and erectile function), cancer specific distress, psychological distress, decision-related distress and time to return to usual activities. Cost modelling of each approach, as well as full economic appraisal, is also being undertaken.
Discussion
The study will provide recommendations about the relative benefits of Robotic and Open Prostatectomy to support informed patient decision making about treatment for localised prostate cancer; and to assist in treatment services planning for this patient group.
Keyword Quality of life
Radical Prostatectomy
Intrusive Thoughts
Health
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article # 189

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2013 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
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