Hydrophilic and amphiphilic polyethylene glycol-based hydrogels with tunable degradability prepared by "click" chemistry

Truong, Vinh, Blakey, Idriss and Whittaker, Andrew K. (2012) Hydrophilic and amphiphilic polyethylene glycol-based hydrogels with tunable degradability prepared by "click" chemistry. Biomacromolecules, 13 12: 4012-4021. doi:10.1021/bm3012924

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Author Truong, Vinh
Blakey, Idriss
Whittaker, Andrew K.
Title Hydrophilic and amphiphilic polyethylene glycol-based hydrogels with tunable degradability prepared by "click" chemistry
Journal name Biomacromolecules   Check publisher's open access policy
ISSN 1525-7797
1526-4602
Publication date 2012-12
Sub-type Article (original research)
DOI 10.1021/bm3012924
Volume 13
Issue 12
Start page 4012
End page 4021
Total pages 10
Place of publication Washington, DC United States
Publisher American Chemical Society
Collection year 2013
Language eng
Formatted abstract
Hydrogels with tunable degradability have potential uses in a range of applications including drug delivery and tissue scaffolds. A series of poly(ethylene glycol) (PEG) hydrogels and amphiphilic PEG-poly(trimethylene carbonate) (PTMC) hydrogels were prepared using copper-catalyzed Huisgen's 1,3-dipolar cycloaddition, or "click" chemistry as the coupling chemistry. The fidelity of the coupling chemistry was confirmed using Fourier transform infrared (FTIR) and 1H magic angle spinning (MAS) NMR spectroscopy while thorough swelling and degradation studies of the hydrogels were performed to relate network structure to the physical properties. The cross-linking efficiency calculated using the Flory-Rehner equation varied from 0.90 to 0.99, which indicates that the networks are close to "ideal" at a molecular level. However, at the microscopic level cryogenic scanning electron microscopy (cryo-SEM) indicated that some degree of phase separation was occurring during cross-linking. At 37 °C and pH 7.4, the degradation rate of the hydrogels increased with decreasing cross-link density in the network. Introduction of PTMC as the cross-linker produced an amphiphilic gel with higher cross-link density and a longer degradation time. The degradability of the resultant hydrogels could thus be tuned through control of molecular weight and structure of the precursors.
Keyword Cross Linked Polymers
Linking Density
Photopolymerization
Copolymers
Morphology
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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