The importance of exposure rate on odds ratios by cigarette smoking and alcohol consumption for esophageal adenocarcinoma and squamous cell carcinoma in the Barrett's Esophagus and Esophageal Adenocarcinoma Consortium

Lubin, Jay H., Cook, Michael B., Pandeya, Nirmala, Vaughan, Thomas L., Abnet, Christian C., Giffen, Carol, Webb, Penelope M., Murray, Liam J., Casson, Alan G., Risch, Harvey A., Ye, Weimin, Kamangar, Farin, Bernstein, Leslie, Sharp, Linda, Nyren, Olof, Gammon, Marilie D., Corley, Douglas A., Wu, Anna H., Brown, Linda M., Chow, Wong-Ho, Ward, Mary H., Freedman, Neal D. and Whiteman, David C. (2012) The importance of exposure rate on odds ratios by cigarette smoking and alcohol consumption for esophageal adenocarcinoma and squamous cell carcinoma in the Barrett's Esophagus and Esophageal Adenocarcinoma Consortium. Cancer Epidemiology, 36 3: 306-316. doi:10.1016/j.canep.2012.03.001


Author Lubin, Jay H.
Cook, Michael B.
Pandeya, Nirmala
Vaughan, Thomas L.
Abnet, Christian C.
Giffen, Carol
Webb, Penelope M.
Murray, Liam J.
Casson, Alan G.
Risch, Harvey A.
Ye, Weimin
Kamangar, Farin
Bernstein, Leslie
Sharp, Linda
Nyren, Olof
Gammon, Marilie D.
Corley, Douglas A.
Wu, Anna H.
Brown, Linda M.
Chow, Wong-Ho
Ward, Mary H.
Freedman, Neal D.
Whiteman, David C.
Title The importance of exposure rate on odds ratios by cigarette smoking and alcohol consumption for esophageal adenocarcinoma and squamous cell carcinoma in the Barrett's Esophagus and Esophageal Adenocarcinoma Consortium
Journal name Cancer Epidemiology   Check publisher's open access policy
ISSN 1877-7821
1877-783X
Publication date 2012-06
Sub-type Article (original research)
DOI 10.1016/j.canep.2012.03.001
Volume 36
Issue 3
Start page 306
End page 316
Total pages 11
Place of publication New York, NY, United States
Publisher Elsevier
Collection year 2012
Language eng
Formatted abstract
Background: Cigarette smoking is associated with esophageal adenocarcinoma (EAC), esophagogastric junctional adenocarcinoma (EGJA) and esophageal squamous cell carcinoma (ESCC), and alcohol consumption with ESCC. However, no analyses have examined how delivery rate modifies the strength of odds ratio (OR) trends with total exposure, i.e., the impact on the OR for a fixed total exposure of high exposure rate for short duration compared with low exposure rate for long duration. Methods: The authors pooled data from 12 case-control studies from the Barrett's Esophagus and Esophageal Adenocarcinoma Consortium (BEACON), including 1242 (EAC), 1263 (EGJA) and 954 (ESCC) cases and 7053 controls, modeled joint ORs for cumulative exposure and exposure rate for cigarette smoking and alcohol consumption, and evaluated effect modification by sex, body mass index (BMI), age and self-reported acid reflux. Results: For smoking, all sites exhibited inverse delivery rate effects, whereby ORs with pack-years increased, but trends weakened with increasing cigarettes/day. None of the examined factors modified associations, except for ESCC where younger ages at diagnosis enhanced smoking effects (P< 0.01). For EAC and EGJA, ORs with drink-years exhibited inverse associations in <5. drinks/day consumers and no association in heavier consumers. For ESCC, ORs with drink-years increased, with trends strengthening with greater drinks/day. There was no significant effect modification, except for EAC and EGJA where acid reflux mitigated the inverse associations (P= 0.02). For ESCC, younger ages at diagnosis enhanced drinking-related ORs (P< 0.01). Conclusions: Patterns of ORs by pack-years and drink-years, delivery rate effects and effect modifiers revealed common as well as distinct etiologic elements for these diseases
Keyword Alcohol drinking
Risk model
Smoking
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Public Health Publications
 
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Created: Fri, 04 Jan 2013, 13:39:15 EST by Geraldine Fitzgerald on behalf of School of Public Health