Inhibitory glycine receptors: an update

Dutertre, Sebastien, Becker, Cord-Michael and Betz, Heinrich (2012) Inhibitory glycine receptors: an update. Journal of Biological Chemistry, 287 48: 40216-40223. doi:10.1074/jbc.R112.408229

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Author Dutertre, Sebastien
Becker, Cord-Michael
Betz, Heinrich
Title Inhibitory glycine receptors: an update
Journal name Journal of Biological Chemistry   Check publisher's open access policy
ISSN 0021-9258
Publication date 2012-11
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1074/jbc.R112.408229
Open Access Status File (Publisher version)
Volume 287
Issue 48
Start page 40216
End page 40223
Total pages 8
Place of publication Bethesda, MD United States
Publisher American Society for Biochemistry and Molecular Biology
Collection year 2012
Language eng
Formatted abstract
Strychnine-sensitive glycine receptors (GlyRs) mediate synaptic inhibition in the spinal cord, brainstem, and other regions of the mammalian central nervous system. In this minireview, we summarize our current view of the structure, ligand-binding sites, and chloride channel of these receptors and discuss recently emerging functions of distinct GlyR isoforms. GlyRs not only regulate the excitability of motor and afferent sensory neurons, including pain fibers, but also are involved in the processing of visual and auditory signals. Hence, GlyRs constitute promising targets for the development of therapeutically useful compounds.
Keyword Gated ion channel
Rat spinal cord slices
Dorsal Horn Neurons
Beta Subunit
Ligand Binding
Chromosomal Localization
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 39 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 43 times in Scopus Article | Citations
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