Congenital urinary tract obstruction: defining markers of developmental kidney injury

Trnka, Peter, Hiatt, Michael J., Tarantal, Alice F. and Matsell, Douglas G. (2012) Congenital urinary tract obstruction: defining markers of developmental kidney injury. Pediatric Research, 72 5: 446-454. doi:10.1038/pr.2012.113


Author Trnka, Peter
Hiatt, Michael J.
Tarantal, Alice F.
Matsell, Douglas G.
Title Congenital urinary tract obstruction: defining markers of developmental kidney injury
Journal name Pediatric Research   Check publisher's open access policy
ISSN 0031-3998
1530-0447
Publication date 2012-11
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/pr.2012.113
Volume 72
Issue 5
Start page 446
End page 454
Total pages 9
Place of publication New York, United States
Publisher Nature Publishing Group
Collection year 2013
Language eng
Abstract Congenital urinary tract obstruction (diagnosed antenatally by ultrasound screening) is one of the main causes of end-stage kidney disease in children. The extent of kidney injury in early gestation and the resultant abnormality in kidney development determine fetal outcome and postnatal renal function. Unfortunately, the current approach to diagnostic evaluation of the severity of injury has inherently poor diagnostic and prognostic value because it is based on the assessment of fetal tubular function from fetal urine samples rather than on estimates of the dysplastic changes in the injured developing kidney. To improve the outcome in children with congenital urinary tract obstruction, new biomarkers reflecting these structural changes are needed. Genomic and proteomic techniques that have emerged in the past decade can help identify the key genes and proteins from biological fluids, including amniotic fluid, that might reflect the extent of injury to the developing kidney.
Keyword Renal potassium-transport
Posterior urethral valves
Fetal kidney
Serum meta(2)-microglobulin
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
School of Medicine Publications
 
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