Association of pre-transplant statin use with delayed graft function in kidney transplant recipients

Reiling, Janske, Johnson, David W., Kruger, Peter S., Pillans, Peter and Wall, Daryl R. (2012) Association of pre-transplant statin use with delayed graft function in kidney transplant recipients. Bmc Nephrology, 13 . doi:10.1186/1471-2369-13-111


Author Reiling, Janske
Johnson, David W.
Kruger, Peter S.
Pillans, Peter
Wall, Daryl R.
Title Association of pre-transplant statin use with delayed graft function in kidney transplant recipients
Journal name Bmc Nephrology   Check publisher's open access policy
ISSN 1471-2369
Publication date 2012-09
Sub-type Article (original research)
DOI 10.1186/1471-2369-13-111
Open Access Status DOI
Volume 13
Total pages 9
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2013
Language eng
Formatted abstract
Background: Administration of HMG-CoA reductase inhibitors (statins), prior to ischemia or prior toreperfusion has been shown to decrease ischemia-reperfusion renal injury in animal studies. Itis unknown whether this protective effect is applicable to renal transplantation in humans.The aim of this study was to determine the relationship between prior statin use in renaltransplant recipients and the subsequent risk of delayed graft function.
Methods: All patients who underwent deceased or living donor renal transplantation at the PrincessAlexandra Hospital between 1 July 2008 and 1 August 2010 were included in thisretrospective, observational cohort study. Graft function was classified as immediate graftfunction (IGF), dialysis-requiring (D-DGF) and non-dialysis-requiring (ND-DGF) delayedgraft function. The independent predictors of graft function were evaluated by multivariablelogistic regression, adjusting for donor characteristics, recipient characteristics, HLAmismatch and ischaemic times.
Results: Overall, of the 266 renal transplant recipients, 21% exhibited D-DGF, 39% had ND-DGF and40% had IGF. Statin use prior to renal transplantation was not significantly associated withthe risk of D-DGF (adjusted odds ratio [OR] 1.05, 95% CI 0.96 - 1.15, P = 0.28). This findingwas not altered when D-DGF and ND-DGF were pooled together (OR 0.98; 95% CI 0.89-1.06, p = 0.56).
Conclusions: The present study did not show a significant, independent association between prior statin usein kidney transplant recipients and the occurrence of delayed graft function.
Keyword Ischemia reperfusion injury
Creatinine Reduction Ratio
Renal transplantation
Controlled Trial
Animal models
New Zealand
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
 
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