Ventilation distribution in rats: Part 2-A comparison of electrical impedance tomography and hyperpolarised helium magnetic resonance imaging

Dunster, Kimble R., Friese, Marlies E. J., Fraser, John F., Galloway, Graham J., Cowin, Gary J. and Schibler, Andreas (2012) Ventilation distribution in rats: Part 2-A comparison of electrical impedance tomography and hyperpolarised helium magnetic resonance imaging. BioMedical Engineering Online, 11 68-1-68-10. doi:10.1186/1475-925X-11-68

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Dunster, Kimble R.
Friese, Marlies E. J.
Fraser, John F.
Galloway, Graham J.
Cowin, Gary J.
Schibler, Andreas
Total Author Count Override 6
Title Ventilation distribution in rats: Part 2-A comparison of electrical impedance tomography and hyperpolarised helium magnetic resonance imaging
Journal name BioMedical Engineering Online   Check publisher's open access policy
ISSN 1475-925X
Publication date 2012-09
Sub-type Article (original research)
DOI 10.1186/1475-925X-11-68
Open Access Status DOI
Volume 11
Start page 68-1
End page 68-10
Total pages 10
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2013
Language eng
Formatted abstract
Background:
Hyperpolarised helium MRI (He3 MRI) is a new technique that enables imaging of the air distribution within the lungs. This allows accurate determination of the ventilation distribution in vivo. The technique has the disadvantages of requiring an expensive helium isotope, complex apparatus and moving the patient to a compatible MRI scanner. Electrical impedance tomography (EIT) a non-invasive bedside technique that allows constant monitoring of lung impedance, which is dependent on changes in air space capacity in the lung. We have used He3MRI measurements of ventilation distribution as the gold standard for assessment of EIT.

Methods:
Seven rats were ventilated in supine, prone, left and right lateral position with 70% helium/30% oxygen for EIT measurements and pure helium for He3 MRI. The same ventilator and settings were used for both measurements. Image dimensions, geometric centre and global in homogeneity index were calculated.

Results:
EIT images were smaller and of lower resolution and contained less anatomical detail than those from He3 MRI. However, both methods could measure positional induced changes in lung ventilation, as assessed by the geometric centre. The global in homogeneity index were comparable between the techniques.

Conclusion:
EIT is a suitable technique for monitoring ventilation distribution and inhomgeneity as assessed by comparison with He3 MRI.
Keyword Electrical impedance tomography
Hyperpolarized helium magnetic resonance lmaging
Ventilation distribution
Functional lung imaging
Lung
Gas
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article number68

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
Centre for Advanced Imaging Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 7 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 16 Dec 2012, 00:40:12 EST by System User on behalf of Centre for Advanced Imaging