A mechanochemical model of striae distensae

Gilmore, Stephen J., Vaughan Jr., Benjamin L., Madzvamuse, Anotida and Maini, Philip K. (2012) A mechanochemical model of striae distensae. Mathematical Biosciences, 240 2: 141-147. doi:10.1016/j.mbs.2012.06.007


Author Gilmore, Stephen J.
Vaughan Jr., Benjamin L.
Madzvamuse, Anotida
Maini, Philip K.
Title A mechanochemical model of striae distensae
Journal name Mathematical Biosciences   Check publisher's open access policy
ISSN 0025-5564
1879-3134
Publication date 2012-12
Sub-type Article (original research)
DOI 10.1016/j.mbs.2012.06.007
Volume 240
Issue 2
Start page 141
End page 147
Total pages 7
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Collection year 2013
Language eng
Abstract Striae distensae, otherwise known as stretch marks, are common skin lesions found in a variety of clinical settings. They occur frequently during adolescence or pregnancy where there is rapid tissue expansion and in clinical situations associated with corticosteroid excess. Heralding their onset is the appearance of parallel inflammatory streaks aligned perpendicular to the direction of skin tension. Despite a considerable amount of investigative research, the pathogenesis of striae remains obscure. The interpretation of histologic samples - the major investigative tool - demonstrates an association between dermal lymphocytic inflammation, elastolysis, and a scarring response. Yet the primary causal factor in their aetiology is mechanical; either skin stretching due to underlying tissue expansion or, less frequently, a compromised dermis affected by normal loads. In this paper, we investigate the pathogenesis of striae by addressing the coupling between mechanical forces and dermal pathology. We develop a mathematical model that incorporates the mechanical properties of cutaneous fibroblasts and dermal extracellular matrix. By using linear stability analysis and numerical simulations of our governing nonlinear equations, we show that this quantitative approach may provide a realistic framework that may account for the initiating events.
Keyword Stretch marks
Mathematical modelling
Numerical simulation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online: 14 July 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 16 Dec 2012, 00:26:46 EST by System User on behalf of Medicine - Princess Alexandra Hospital