The effect of increased oxidative stress and ferritin in reducing the effectiveness of therapy in chronic hepatitis C patients

Chiou, Ya-Lin, Chen, Yi-Hui, Ke, Tiffany and Ko, Wang-Sheng (2012) The effect of increased oxidative stress and ferritin in reducing the effectiveness of therapy in chronic hepatitis C patients. Clinical Biochemistry, 45 16-17: 1389-1393. doi:10.1016/j.clinbiochem.2012.06.026


Author Chiou, Ya-Lin
Chen, Yi-Hui
Ke, Tiffany
Ko, Wang-Sheng
Title The effect of increased oxidative stress and ferritin in reducing the effectiveness of therapy in chronic hepatitis C patients
Journal name Clinical Biochemistry   Check publisher's open access policy
ISSN 0009-9120
1873-2933
Publication date 2012-11
Sub-type Article (original research)
DOI 10.1016/j.clinbiochem.2012.06.026
Volume 45
Issue 16-17
Start page 1389
End page 1393
Total pages 5
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Collection year 2013
Language eng
Formatted abstract
Background/aim: Chronic hepatitis C (CHC) patients have higher oxidative stress and ferritin than healthy individuals. However, the level of oxidative stress in CHC patients during treatment with peginterferon alpha-2a and ribavirin is not clear. The aims of our study are to investigate changes of thiobarbituric acid reactive substances (TBARS; indicated oxidative stress), total antioxidant status (TAS) and ferritin in CHC patients during therapy and to identify the correlation of these factors and the effectiveness of therapy.
Methods: Sixty CHC patients were selected and were prescribed 180 μg of peginteferon alpha-2a once a week and a daily dose of 1000 to 1200 mg ribavirin for 6 months. Throughout the treatment course, blood samples were taken to determine TBARS, TAS, and liver inflammation profiles including ferritin, aspartate transaminase (AST) and alanine transaminase (ALT).
Results: The level of TBARS increased before the 12th week of therapy. Additionally, the levels of TBARS were higher in nonā€rapid virological response (RVR) patients compared with RVR (p < 0.01) in baseline and therapy at the 24th week. TAS was lower during therapy than at baseline. Levels of TAS were significantly higher in sustained virological response (SVR) patients than in non-SVR (p < 0.01) in the 4th week post-therapy. We also found a positive correlation between the level of ferritin and liver inflammation during treatment (p < 0.01). The levels of ferritin and ALT were lower in SVR than in non-SVR patients in the 4th week of post-therapy (p < 0.01).
Conclusions: This study indicated that decreased ferritin, decreased TBARS and increased TAS status may improve the efficacy of treatment.
Keyword Chronic hepatitis C
Oxidative pressure
TBARS
TAS
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Biomedical Sciences Publications
 
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