Global variation in the prevalence and incidence of major depressive disorder: a systematic review of the epidemiological literature

Ferrari, A. J., Somerville, A. J., Baxter, A. J., Norman, R., Patten, S. B., Vos, T. and Whiteford, H. (2013) Global variation in the prevalence and incidence of major depressive disorder: a systematic review of the epidemiological literature. Psychological Medicine, 43 3: 471-481. doi:10.1017/S0033291712001511


Author Ferrari, A. J.
Somerville, A. J.
Baxter, A. J.
Norman, R.
Patten, S. B.
Vos, T.
Whiteford, H.
Title Global variation in the prevalence and incidence of major depressive disorder: a systematic review of the epidemiological literature
Journal name Psychological Medicine   Check publisher's open access policy
ISSN 0033-2917
1469-8978
Publication date 2013-03
Year available 2012
Sub-type Article (original research)
DOI 10.1017/S0033291712001511
Open Access Status
Volume 43
Issue 3
Start page 471
End page 481
Total pages 12
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Collection year 2013
Language eng
Formatted abstract
Background: Summarizing the epidemiology of major depressive disorder (MDD) at a global level is complicated by significant heterogeneity in the data. The aim of this study is to present a global summary of the prevalence and incidence of MDD, accounting for sources of bias, and dealing with heterogeneity. Findings are informing MDD burden quantification in the Global Burden of Disease (GBD) 2010 Study.

Method: A systematic review of prevalence and incidence of MDD was undertaken. Electronic databases Medline, PsycINFO and EMBASE were searched. Community-representative studies adhering to suitable diagnostic nomenclature were included. A meta-regression was conducted to explore sources of heterogeneity in prevalence and guide the stratification of data in a meta-analysis.

Results: The literature search identified 116 prevalence and four incidence studies. Prevalence period, sex, year of study, depression subtype, survey instrument, age and region were significant determinants of prevalence, explaining 57.7% of the variability between studies. The global point prevalence of MDD, adjusting for methodological differences, was 4.7% (4.4–5.0 %). The pooled annual incidence was 3.0% (2.4–3.8 %), clearly at odds with the pooled prevalence estimates and the previously reported average duration of 30 weeks for an episode of MDD.

Conclusions: Our findings provide a comprehensive and up-to-date profile of the prevalence of MDD globally. Region and study methodology influenced the prevalence of MDD. This needs to be considered in the GBD 2010 study and in investigations into the ecological determinants of MDD. Good-quality estimates from low-/middle-income countries were sparse. More accurate data on incidence are also required.
Keyword Epidemiology
Global burden of disease
Incidence
Major depressive disorder
Meta-regression
Prevalence
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 25 July 2012

 
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Created: Wed, 12 Dec 2012, 15:55:00 EST by Geraldine Fitzgerald on behalf of School of Public Health