Frozen blood products: clinically effective and potentially ideal for remote Australia

Holley, Anthony, Marks, Denese, Johnson, L., Reade, Michael C., Badloe, J. and Noorman, F. (2013) Frozen blood products: clinically effective and potentially ideal for remote Australia. Anaesthesia and Intensive Care, 41 1: 10-19.

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Author Holley, Anthony
Marks, Denese
Johnson, L.
Reade, Michael C.
Badloe, J.
Noorman, F.
Title Frozen blood products: clinically effective and potentially ideal for remote Australia
Journal name Anaesthesia and Intensive Care   Check publisher's open access policy
ISSN 0310-057X
1448-0271
Publication date 2013
Sub-type Critical review of research, literature review, critical commentary
Open Access Status
Volume 41
Issue 1
Start page 10
End page 19
Total pages 10
Place of publication Edgecliff, NSW, Australia
Publisher Australian Society of Anaesthetists
Collection year 2014
Language eng
Abstract The development of effective cryopreservation techniques for both red blood cells and platelets, which maintain ex vivo biological activity, in combination with frozen plasma, provides for a unique blood banking strategy. This technology greatly enhances the storage life of these products. The rationale and potential advantages of using cryopreservation techniques for the provision of blood products to remote and military environments have been effectively demonstrated in several conflicts over the last decade. Current haemostatic resuscitation doctrine for the exsanguinating patient supports the use of red blood cells, platelets and frozen plasma early in the resuscitation. We believe an integrated fresh–frozen blood bank inventory could facilitate provision of blood products, not only in the military setting but also in regional Australia, by overcoming many logistic and geographical challenges. The processes involved in production and point of care thawing are sufficiently well developed and achievable to make this technology a viable option. The potential limitations of cryopreservation and subsequent product thawing need to be considered if such a strategy is to be developed. A substantial body of international experience using cryopreserved products in remote settings has already been accrued. This experience provides a template for the possible creation of an Australian integrated fresh–frozen blood bank inventory that could conceivably enhance the care of patients in both regional Australia and in the military setting.
Keyword Platelets
Plasma
Red blood cells
Dimethyl sulfoxide
Glycerol
Cryopreserved
Deep frozen
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Accepted for publication 26 Nov 2012

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Medicine Publications
 
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Created: Mon, 10 Dec 2012, 18:40:17 EST by Sia Athanasas on behalf of Anaesthesiology and Critical Care - RBWH