Mathematical model for growth regulation of fission yeast Schizosaccharomyces pombe

Cerone, Luca, Novak, Bela and Neufeld, Zoltan (2012) Mathematical model for growth regulation of fission yeast Schizosaccharomyces pombe. PLoS One, 7 11: e49675.1-e49675.11. doi:10.1371/journal.pone.0049675


Author Cerone, Luca
Novak, Bela
Neufeld, Zoltan
Title Mathematical model for growth regulation of fission yeast Schizosaccharomyces pombe
Formatted title
Mathematical model for growth regulation of fission yeast Schizosaccharomyces pombe
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2012-11
Sub-type Article (original research)
DOI 10.1371/journal.pone.0049675
Open Access Status DOI
Volume 7
Issue 11
Start page e49675.1
End page e49675.11
Total pages 11
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Collection year 2013
Language eng
Abstract Regulation of polarised cell growth is essential for many cellular processes including spatial coordination of cell morphology changes during the division cycle. We present a mathematical model of the core mechanism responsible for the regulation of polarised growth dynamics during the fission yeast cell cycle. The model is based on the competition of growth zones localised at the cell tips for a common substrate distributed uniformly in the cytosol. We analyse the bifurcations in this model as the cell length increases, and show that the growth activation dynamics provides an explanation for the new-end take-off (NETO) as a saddle-node bifurcation at which the cell sharply switches from monopolar to bipolar growth. We study the parameter sensitivity of the bifurcation diagram and relate qualitative changes of the growth pattern, e.g. delayed or absent NETO, to previously observed mutant phenotypes. We investigate the effects of imperfect asymmetric cell division, and show that this leads to distinct growth patterns that provide experimentally testable predictions for validating the presented competitive growth zone activation model. Finally we discuss extension of the model for describing mutant cells with more than two growth zones.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article # e49675

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Mathematics and Physics
Official 2013 Collection
 
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Created: Mon, 10 Dec 2012, 16:26:34 EST by Zoltan Neufeld on behalf of Mathematics