Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies

Neugut, A., Santella, R., Baines, C. J., Kreiger, N., Miller, A. B., Wall, C., Tjonneland, A., Jorgensen, T., Stahlberg, C., Pedersen, A. Tonnes, Flesch-Janys, D., Hakansson, N., Cauley, J., Heuch, I., Adami, H. O., Persson, I., Weiderpass, E., Magnusson, C., Chang-Claude, J., Kaaks, R., McCredie, M., Paul, C., Skegg, D. C. G., Spears, G. F. S., Iwasaki, M., Tsugane, S., Anderson, G., Daling, J. R., Hampton, J., Hutchinson, W. B., Li, C. I., Malone, K., Mandelson, M., Newcomb, P., Noonan, E. A., Ray, R. M., Stanford, J. L., Tang, M. T. C., Thomas, D. B., Weiss, N. S., White, E., Izquierdo, A., Viladiu, P., Fourkala, E. O., Jacobs, I., Menon, U., Ryan, A., Cuevas, H. R., Ontiveros, P., Palet, A., Salazar, S. B., Aristizabal, N., Cuadros, A., Tryggvadottir, L., Tulinius, H., Riboli, E., Andrieu, N., Bachelot, A., Le, M. G., Bremond, A., Gairard, B., Lansac, J., Piana, L., Renaud, R., Clavel-Chapelon, F., Fournier, A., Touillaud, M., Mesrine, S., Chabbert-Buffet, N., Boutron-Ruault, M. C., Wolk, A., Torres-Mejia, G., Franceschi, S., Romieu, I., Boyle, P., Lubin, F., Modan, B., Ron, E., Wax, Y., Friedman, G. D., Hiatt, R. A., Levi, F., Kosmelj, K., Primic-Zakelj, M., Ravnihar, B., Stare, J., Ekbom, A., Erlandsson, G., Persson, I., Beeson, W. L., Fraser, G., Peto, J., Hanson, R. L., Leske, M. C., Mahoney, M. C., Nasca, P. C., Varma, A. O., Weinstein, A. L., Hartman, M. L., Olsson, H., Goldbohm, R. A., van den Brandt, P. A., Palli, D., Teitelbaum, S., Apelo, R. A., Baens, J., de la Cruz, J. R., Javier, B., Lacaya, L. B., Ngelangel, C. A., La Vecchia, C., Negri, E., Marubini, E., Ferraroni, M., Pike, M. C., Gerber, M., Richardson, S., Segala, C., Gatei, D., Kenya, P., Kungu, A., Mati, J. G., Brinton, L. A., Freedman, M., Hoover, R., Schairer, C., Ziegler, R., Banks, E., Spirtas, R., Lee, H. P., Rookus, M. A., van Leeuwen, F. E., Schoenberg, J. A., Graff-Iversen, S., Selmer, R., Jones, L., McPherson, K., Neil, A., Vessey, M., Yeates, D., Mabuchi, K., Preston, D., Hannaford, P., Kay, C., McCann, S. E., Rosero-Bixby, L., Gao, Y. T., Jin, F., Yuan, J-M, Wei, H. Y., Yun, T., Zhiheng, C., Berry, G., Booth, J. Cooper, Jelihovsky, T., MacLennan, R., Shearman, R., Hadjisavvas, A., Kyriacou, K., Loisidou, M., Zhou, X., Wang, Q-S, Kawai, M., Minami, Y., Tsuji, I., Lund, E., Kumle, M., Stalsberg, H., Shu, X. O., Zheng, W., Monninkhof, E. M., Onland-Moret, N. C., Peeters, P. H. M., Katsouyanni, K., Trichopoulou, A., Trichopoulos, D., Tzonou, A., Baltzell, K. A., Dabancens, A., Martinez, L., Molina, R., Salas, O., Alexander, F. E., Anderson, K., Folsom, A. R., Gammon, M. D., Hulka, B. S., Millikan, R., Chilvers, C. E. D., Lumachi, F., Bain, C., Schofield, F., Siskind, V., Rebbeck, T. R., Bernstein, L. R., Enger, S., Haile, R. W., Paganini-Hill, A., Ross, R. K., Ursin, G., Wu, A. H., Yu, M. C., Ewertz, Denmark M., Clarke, E. A., Bergkvist, L., Anderson, G. L., Gass, M., O'Sullivan, M. J., Kalache, A., Farley, T. M. M., Holck, S., Meirik, O., Fukao, A. and Collaborative Group on Hormonal Factors in Breast Cancer (2012) Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies. Lancet Oncology, 13 11: 1141-1151. doi:10.1016/S1470-2045(12)70425-4


Author Neugut, A.
Santella, R.
Baines, C. J.
Kreiger, N.
Miller, A. B.
Wall, C.
Tjonneland, A.
Jorgensen, T.
Stahlberg, C.
Pedersen, A. Tonnes
Flesch-Janys, D.
Hakansson, N.
Cauley, J.
Heuch, I.
Adami, H. O.
Persson, I.
Weiderpass, E.
Magnusson, C.
Chang-Claude, J.
Kaaks, R.
McCredie, M.
Paul, C.
Skegg, D. C. G.
Spears, G. F. S.
Iwasaki, M.
Tsugane, S.
Anderson, G.
Daling, J. R.
Hampton, J.
Hutchinson, W. B.
Li, C. I.
Malone, K.
Mandelson, M.
Newcomb, P.
Noonan, E. A.
Ray, R. M.
Stanford, J. L.
Tang, M. T. C.
Thomas, D. B.
Weiss, N. S.
White, E.
Izquierdo, A.
Viladiu, P.
Fourkala, E. O.
Jacobs, I.
Menon, U.
Ryan, A.
Cuevas, H. R.
Ontiveros, P.
Palet, A.
Salazar, S. B.
Aristizabal, N.
Cuadros, A.
Tryggvadottir, L.
Tulinius, H.
Riboli, E.
Andrieu, N.
Bachelot, A.
Le, M. G.
Bremond, A.
Gairard, B.
Lansac, J.
Piana, L.
Renaud, R.
Clavel-Chapelon, F.
Fournier, A.
Touillaud, M.
Mesrine, S.
Chabbert-Buffet, N.
Boutron-Ruault, M. C.
Wolk, A.
Torres-Mejia, G.
Franceschi, S.
Romieu, I.
Boyle, P.
Lubin, F.
Modan, B.
Ron, E.
Wax, Y.
Friedman, G. D.
Hiatt, R. A.
Levi, F.
Kosmelj, K.
Primic-Zakelj, M.
Ravnihar, B.
Stare, J.
Ekbom, A.
Erlandsson, G.
Persson, I.
Beeson, W. L.
Fraser, G.
Peto, J.
Hanson, R. L.
Leske, M. C.
Mahoney, M. C.
Nasca, P. C.
Varma, A. O.
Weinstein, A. L.
Hartman, M. L.
Olsson, H.
Goldbohm, R. A.
van den Brandt, P. A.
Palli, D.
Teitelbaum, S.
Apelo, R. A.
Baens, J.
de la Cruz, J. R.
Javier, B.
Lacaya, L. B.
Ngelangel, C. A.
La Vecchia, C.
Negri, E.
Marubini, E.
Ferraroni, M.
Pike, M. C.
Gerber, M.
Richardson, S.
Segala, C.
Gatei, D.
Kenya, P.
Kungu, A.
Mati, J. G.
Brinton, L. A.
Freedman, M.
Hoover, R.
Schairer, C.
Ziegler, R.
Banks, E.
Spirtas, R.
Lee, H. P.
Rookus, M. A.
van Leeuwen, F. E.
Schoenberg, J. A.
Graff-Iversen, S.
Selmer, R.
Jones, L.
McPherson, K.
Neil, A.
Vessey, M.
Yeates, D.
Mabuchi, K.
Preston, D.
Hannaford, P.
Kay, C.
McCann, S. E.
Rosero-Bixby, L.
Gao, Y. T.
Jin, F.
Yuan, J-M
Wei, H. Y.
Yun, T.
Zhiheng, C.
Berry, G.
Booth, J. Cooper
Jelihovsky, T.
MacLennan, R.
Shearman, R.
Hadjisavvas, A.
Kyriacou, K.
Loisidou, M.
Zhou, X.
Wang, Q-S
Kawai, M.
Minami, Y.
Tsuji, I.
Lund, E.
Kumle, M.
Stalsberg, H.
Shu, X. O.
Zheng, W.
Monninkhof, E. M.
Onland-Moret, N. C.
Peeters, P. H. M.
Katsouyanni, K.
Trichopoulou, A.
Trichopoulos, D.
Tzonou, A.
Baltzell, K. A.
Dabancens, A.
Martinez, L.
Molina, R.
Salas, O.
Alexander, F. E.
Anderson, K.
Folsom, A. R.
Gammon, M. D.
Hulka, B. S.
Millikan, R.
Chilvers, C. E. D.
Lumachi, F.
Bain, C.
Schofield, F.
Siskind, V.
Rebbeck, T. R.
Bernstein, L. R.
Enger, S.
Haile, R. W.
Paganini-Hill, A.
Ross, R. K.
Ursin, G.
Wu, A. H.
Yu, M. C.
Ewertz, Denmark M.
Clarke, E. A.
Bergkvist, L.
Anderson, G. L.
Gass, M.
O'Sullivan, M. J.
Kalache, A.
Farley, T. M. M.
Holck, S.
Meirik, O.
Fukao, A.
Collaborative Group on Hormonal Factors in Breast Cancer
Total Author Count Override 305
Title Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies
Journal name Lancet Oncology   Check publisher's open access policy
ISSN 1470-2045
1474-5488
Publication date 2012-11
Sub-type Article (original research)
DOI 10.1016/S1470-2045(12)70425-4
Volume 13
Issue 11
Start page 1141
End page 1151
Total pages 11
Place of publication London, United Kingdom
Publisher Lancet Publishing
Collection year 2013
Language eng
Formatted abstract
Background: Menarche and menopause mark the onset and cessation, respectively, of ovarian activity associated with reproduction, and affect breast cancer risk. Our aim was to assess the strengths of their effects and determine whether they depend on characteristics of the tumours or the affected women.

Methods: Individual data from 117 epidemiological studies, including 118 964 women with invasive breast cancer and 306 091 without the disease, none of whom had used menopausal hormone therapy, were included in the analyses. We calculated adjusted relative risks (RRs) associated with menarche and menopause for breast cancer overall, and by tumour histology and by oestrogen receptor expression.

Findings: Breast cancer risk increased by a factor of 1·050 (95% CI 1·044-1·057; p<0·0001) for every year younger at menarche, and independently by a smaller amount (1·029, 1·025-1·032; p<0·0001), for every year older at menopause. Premenopausal women had a greater risk of breast cancer than postmenopausal women of an identical age (RR at age 45-54 years 1·43, 1·33-1·52, p<0·001). All three of these associations were attenuated by increasing adiposity among postmenopausal women, but did not vary materially by women's year of birth, ethnic origin, childbearing history, smoking, alcohol consumption, or hormonal contraceptive use. All three associations were stronger for lobular than for ductal tumours (p<0·006 for each comparison). The effect of menopause in women of an identical age and trends by age at menopause were stronger for oestrogen receptor-positive disease than for oestrogen receptor-negative disease (p<0·01 for both comparisons).

Interpretation: The effects of menarche and menopause on breast cancer risk might not be acting merely by lengthening women's total number of reproductive years. Endogenous ovarian hormones are more relevant for oestrogen receptor-positive disease than for oestrogen receptor-negative disease and for lobular than for ductal tumours.
Keyword Collaborative reanalysis
Postmenopausal women
Sex-hormones
Age
Therapy
Patient
Trials
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published Online: 17 October 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
 
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