GH mediates exercise-dependent activation of SVZ neural precursor cells in aged mice

Blackmore, Daniel G., Vukovic, Jana, Waters, Michael J. and Bartlett, Perry F. (2012) GH mediates exercise-dependent activation of SVZ neural precursor cells in aged mice. PLoS One, 7 11: e49912.1-e49912.7. doi:10.1371/journal.pone.0049912

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Author Blackmore, Daniel G.
Vukovic, Jana
Waters, Michael J.
Bartlett, Perry F.
Title GH mediates exercise-dependent activation of SVZ neural precursor cells in aged mice
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2012-12
Sub-type Article (original research)
DOI 10.1371/journal.pone.0049912
Open Access Status DOI
Volume 7
Issue 11
Start page e49912.1
End page e49912.7
Total pages 7
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Collection year 2013
Language eng
Abstract Here we demonstrate, both in vivo and in vitro, that growth hormone (GH) mediates precursor cell activation in the subventricular zone (SVZ) of the aged (12-month-old) brain following exercise, and that GH signaling stimulates precursor activation to a similar extent to exercise. Our results reveal that both addition of GH in culture and direct intracerebroventricular infusion of GH stimulate neural precursor cells in the aged brain. In contrast, no increase in neurosphere numbers was observed in GH receptor null animals following exercise. Continuous infusion of a GH antagonist into the lateral ventricle of wild-type animals completely abolished the exercise-induced increase in neural precursor cell number. Given that the aged brain does not recover well after injury, we investigated the direct effect of exercise and GH on neural precursor cell activation following irradiation. This revealed that physical exercise as well as infusion of GH promoted repopulation of neural precursor cells in irradiated aged animals. Conversely, infusion of a GH antagonist during exercise prevented recovery of precursor cells in the SVZ following irradiation.
Keyword Growth hormone
Subventricular zone (SVZ)
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article number e49912 Published on: 27 November 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2013 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 8 times in Scopus Article | Citations
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Created: Fri, 07 Dec 2012, 12:11:14 EST by Debra McMurtrie on behalf of Queensland Brain Institute