Systematic review of progesterone use by midlife and menopausal women

Spark, M. Joy and Willis, Jon (2012) Systematic review of progesterone use by midlife and menopausal women. Maturitas, 72 3: 192-202.


Author Spark, M. Joy
Willis, Jon
Title Systematic review of progesterone use by midlife and menopausal women
Journal name Maturitas   Check publisher's open access policy
ISSN 0378-5122
1873-4111
Publication date 2012-07
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.maturitas.2012.03.015
Volume 72
Issue 3
Start page 192
End page 202
Total pages 11
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier
Collection year 2013
Language eng
Formatted abstract Progesterone treatment for menopausal symptoms is still controversial. Progesterone levels fall during menopause transition, therefore some menopausal women may benefit from progesterone therapy. A systematic review was conducted of studies published from 2001 reporting on progesterone use to treat symptoms associated with menopause or postmenopausal women. Fourteen data bases were searched using the search terms progesterone, menopause, aged, female and human; exclusions were breast cancer, animal and contraception.

Thirteen studies were selected for inclusion (11 clinical trials, 1 cohort study and 1 qualitative study), evaluating progesterone effects on menopausal symptoms, bone, sleep, skin, cognition, plasma lipids and plaque progression. Most studies were of low methodological quality (GRADE low or very low). Progesterone improved vasomotor symptoms and sleep quality, with minimal risk. Large studies designed to identify confounders, such as hormone levels, menopausal status and metabolism are required to understand the place of progesterone in clinical practice.
Keyword Menopause symptoms
Midlife
Postmenopause
Progesterone
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Aboriginal and Torres Strait Islander Studies Unit Publications
Non HERDC
 
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Created: Thu, 06 Dec 2012, 12:29:35 EST by Jon Willis on behalf of Aboriginal and Torres Strait Islander Studies Unit