Brevianamides with antitubercular potential from a marine-derived isolate of aspergillus versicolor

Song, Fuhang, Liu, Xinru, Guo, Hui, Ren, Biao, Chen, Caixia, Piggott, Andrew M., Yu, Ke, Gao, Hong, Wang, Qian, Liu, Mei, Liu, Xueting, Dai, Huanqin, Zhang, Lixin and Capon, Robert J. (2012) Brevianamides with antitubercular potential from a marine-derived isolate of aspergillus versicolor. Organic Letters, 14 18: 4770-4773. doi:10.1021/ol302051x


Author Song, Fuhang
Liu, Xinru
Guo, Hui
Ren, Biao
Chen, Caixia
Piggott, Andrew M.
Yu, Ke
Gao, Hong
Wang, Qian
Liu, Mei
Liu, Xueting
Dai, Huanqin
Zhang, Lixin
Capon, Robert J.
Title Brevianamides with antitubercular potential from a marine-derived isolate of aspergillus versicolor
Journal name Organic Letters   Check publisher's open access policy
ISSN 1523-7060
1523-7052
Publication date 2012-09
Sub-type Article (original research)
DOI 10.1021/ol302051x
Volume 14
Issue 18
Start page 4770
End page 4773
Total pages 4
Place of publication Washington, DC, United States
Publisher American Chemical Society
Collection year 2013
Language eng
Abstract An Aspergillus versicolor isolated from sediment collected from the Bohai Sea, China, yielded the new dimeric diketopiperazine brevianamide S (1), together with three new monomeric cometabolites, brevianamides T (2), U (3), and V (4). Structures were determined by detailed spectroscopic analysis. Brevianamide S exhibited selective antibacterial activity against Bacille Calmette-Guérin (BCG), suggestive of a new mechanism of action that could inform the development of next-generation antitubercular drugs.
Keyword Tuberculosis drug development
Natural-products
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Publication Date (Web): September 10, 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Institute for Molecular Bioscience - Publications
 
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