Adenosine-diphosphate (ADP) receptor antagonists for the prevention of cardiovascular disease in type 2 diabetes mellitus

Valentine, Nyoli, Van de Laar, Floris A. and van Driel, Mieke L. (2012) Adenosine-diphosphate (ADP) receptor antagonists for the prevention of cardiovascular disease in type 2 diabetes mellitus. Cochrane Database of Systematic Reviews, 11: .


Author Valentine, Nyoli
Van de Laar, Floris A.
van Driel, Mieke L.
Title Adenosine-diphosphate (ADP) receptor antagonists for the prevention of cardiovascular disease in type 2 diabetes mellitus
Journal name Cochrane Database of Systematic Reviews   Check publisher's open access policy
ISSN 1469-493X
Publication date 2012
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/14651858.CD005449.pub2
Issue 11
Total pages 57
Place of publication Oxford United Kingdom
Publisher John Wiley and Sons
Collection year 2013
Language eng
Formatted abstract Background
Cardiovascular disease (CVD) is the most prevalent complication of type 2 diabetes with an estimated 65% of people with type 2 diabetes dying from a cause related to atherosclerosis. Adenosine-diphosphate (ADP) receptor antagonists like clopidogrel, ticlopidine, prasugrel and ticagrelor impair platelet aggregation and fibrinogen-mediated platelet cross-linking and may be effective in preventing CVD.
Objectives
To assess the effects of adenosine-diphosphate (ADP) receptor antagonists for the prevention of cardiovascular disease in type 2 diabetes mellitus.
Search methods
We searched the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library (issue 2, 2011), MEDLINE (until April 2011) and EMBASE (until May 2011). We also performed a manual search, checking references of original articles and pertinent reviews to identify additional studies.
Selection criteria
Randomised controlled trials comparing an ADP receptor antagonist with another antiplatelet agent or placebo for a minimum of 12 months in patients with diabetes. In particular, we looked for trials assessing clinical cardiovascular outcomes.
Data collection and analysis
Two review authors extracted data for studies which fulfilled the inclusion criteria, using standard data extraction templates.We sought additional unpublished information and data from the principal investigators of all included studies.
Keyword Cardiovascualr disease
Type 2 Diabetes
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes 11 Art. No.: CD005449.; [Intervention Review]

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Discipline of General Practice Publications
Official 2013 Collection
School of Medicine Publications
 
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Created: Tue, 27 Nov 2012, 15:28:25 EST by Shani Lamb on behalf of Discipline of General Practice