Dysregulation of the hypothalamic pituitary adrenal (HPA) axis and physical performance at older ages: an individual participant meta-analysis

Gardner, Michael P., Lightman, Stafford, Sayer, Avan Aihie, Cooper, Cyrus, Cooper, Rachel, Deeg, Dorly, Ebrahim, Shah, Gallacher, John, Kivimaki, Mika, Kumari, Meena, Kuh, Diana, Martin, Richard M., Peeters, Geeske, Ben-Shlomo, Yoav and Halcyon Study Team (2012) Dysregulation of the hypothalamic pituitary adrenal (HPA) axis and physical performance at older ages: an individual participant meta-analysis. Psychoneuroendocrinology, 38 1: 40-49. doi:10.1016/j.psyneuen.2012.04.016


Author Gardner, Michael P.
Lightman, Stafford
Sayer, Avan Aihie
Cooper, Cyrus
Cooper, Rachel
Deeg, Dorly
Ebrahim, Shah
Gallacher, John
Kivimaki, Mika
Kumari, Meena
Kuh, Diana
Martin, Richard M.
Peeters, Geeske
Ben-Shlomo, Yoav
Halcyon Study Team
Total Author Count Override 40
Title Dysregulation of the hypothalamic pituitary adrenal (HPA) axis and physical performance at older ages: an individual participant meta-analysis
Journal name Psychoneuroendocrinology   Check publisher's open access policy
ISSN 0306-4530
1873-3360
Publication date 2012-05-31
Sub-type Article (original research)
DOI 10.1016/j.psyneuen.2012.04.016
Volume 38
Issue 1
Start page 40
End page 49
Total pages 10
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon
Collection year 2013
Language eng
Abstract The association between functioning of the hypothalamic pituitary adrenal (HPA) axis and physical performance at older ages remains poorly understood. We carried out meta-analyses to test the hypothesis that dysregulation of the HPA axis, as indexed by patterns of diurnal cortisol release, is associated with worse physical performance. Data from six adult cohorts (ages 50-92 years) were included in a two stage meta-analysis of individual participant data. We analysed each study separately using linear and logistic regression models and then used meta-analytic methods to pool the results. Physical performance outcome measures were walking speed, balance time, chair rise time and grip strength. Exposure measures were morning (serum and salivary) and evening (salivary) cortisol. Total sample sizes in meta-analyses ranged from n = 2146 for associations between morning Cortisol Awakening Response and balance to n = 8448 for associations between morning cortisol and walking speed. A larger diurnal drop was associated with faster walking speed (standardised coefficient per SD increase 0.052, 95% confidence interval (CI) 0.029, 0.076, p < 0.001; age and gender adjusted) and a quicker chair rise time (standardised coefficient per SD increase -0.075, 95% CI -0.116, -0.034, p < 0.001; age and gender adjusted). There was little evidence of associations with balance or grip strength. Greater diurnal decline of the HPA axis is associated with better physical performance in later life. This may reflect a causal effect of the HPA axis on performance or that other ageing-related factors are associated with both reduced HPA reactivity and performance.
Keyword Healthy ageing
HPA axis
Physical capability
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online: 31 May 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Public Health Publications
School of Human Movement and Nutrition Sciences Publications
 
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Created: Tue, 27 Nov 2012, 11:49:55 EST by Deborah Noon on behalf of School of Human Movement and Nutrition Sciences