The role of epigenetic mechanisms and processes in autoimmune disorders

Greer, Judith M. and McCombe, Pamela A. (2012) The role of epigenetic mechanisms and processes in autoimmune disorders. Biologics: Targets and Therapy, 6 307-327. doi:10.2147/BTT.S24067


Author Greer, Judith M.
McCombe, Pamela A.
Title The role of epigenetic mechanisms and processes in autoimmune disorders
Journal name Biologics: Targets and Therapy   Check publisher's open access policy
ISSN 1177-5475
1177-5491
Publication date 2012-09-06
Sub-type Article (original research)
DOI 10.2147/BTT.S24067
Open Access Status DOI
Volume 6
Start page 307
End page 327
Total pages 21
Place of publication Auckland, New Zealand
Publisher Dove Medical Press
Collection year 2013
Language eng
Abstract The lack of complete concordance of autoimmune disease in identical twins suggests that nongenetic factors play a major role in determining disease susceptibility. In this review, we consider how epigenetic mechanisms could affect the immune system and effector mechanisms in autoimmunity and/or the target organ of autoimmunity and thus affect the development of autoimmune diseases. We also consider the types of stimuli that lead to epigenetic modifications and how these relate to the epidemiology of autoimmune diseases and the biological pathways operative in different autoimmune diseases. Increasing our knowledge of these epigenetic mechanisms and processes will increase the prospects for controlling or preventing autoimmune diseases in the future through the use of drugs that target the epigenetic pathways.
Keyword Twins
Concordance
Autoimmune disease
Nongenetic factors
Immune system
Epigenetic modifications
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2013 Collection
School of Medicine Publications
 
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Created: Mon, 26 Nov 2012, 12:48:08 EST by Judith M Greer on behalf of UQ Centre for Clinical Research