Phylogeny rather than ecology or lifestyle biases the construction of Escherichia coli-Shigella genetic exchange communities

Skippington, Elizabeth and Ragan, Mark A. (2012) Phylogeny rather than ecology or lifestyle biases the construction of Escherichia coli-Shigella genetic exchange communities. Open Biology, 2 SEP: . doi:10.1098/rsob.120112


Author Skippington, Elizabeth
Ragan, Mark A.
Title Phylogeny rather than ecology or lifestyle biases the construction of Escherichia coli-Shigella genetic exchange communities
Formatted title
Phylogeny rather than ecology or lifestyle biases the construction of Escherichia coli-Shigella genetic exchange communities
Journal name Open Biology   Check publisher's open access policy
ISSN 2046-2441
Publication date 2012-09
Sub-type Article (original research)
DOI 10.1098/rsob.120112
Open Access Status DOI
Volume 2
Issue SEP
Total pages 14
Place of publication London, United Kingdom
Publisher The Royal Society Publishing
Collection year 2013
Language eng
Formatted abstract
Genetic material can be transmitted not only vertically from parent to offspring, but also laterally (horizontally) from one bacterial lineage to another. Lateral genetic transfer is non-uniform; biases in its nature or frequency construct communities of genetic exchange. These biases have been proposed to arise from phylogenetic relatedness, shared ecology and/or common lifestyle. Here, we test these hypotheses using a graph-based abstraction of inferred genetic-exchange relationships among 27 Escherichia coli and Shigella genomes. We show that although barriers to inter-phylogenetic group lateral transfer are low, E. coli and Shigella are more likely to have exchanged genetic material with close relatives. We find little evidence of bias arising from shared environment or lifestyle. More than one-third of donor–recipient pairs in our analysis show some level of fragmentary gene transfer. Thus, within the E. coli–Shigella clade, intact genes and gene fragments have been disseminated non-uniformly and at appreciable frequency, constructing communities that transgress environmental and lifestyle boundaries.
Keyword Lateral genetic transfer
Horizontal genetic transfer
Genetic exchange communities
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online September 12, 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Institute for Molecular Bioscience - Publications
 
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