Mincle polarizes human monocyte and neutrophil responses to Candida albicans

Vijayan, Dipti, Radford, Kristen J., Beckhouse, Anthony G., Ashman, Robert B. and Wells, Christine A. (2012) Mincle polarizes human monocyte and neutrophil responses to Candida albicans. Immunology and Cell Biology, 90 9: 889-895. doi:10.1038/icb.2012.24

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Author Vijayan, Dipti
Radford, Kristen J.
Beckhouse, Anthony G.
Ashman, Robert B.
Wells, Christine A.
Title Mincle polarizes human monocyte and neutrophil responses to Candida albicans
Journal name Immunology and Cell Biology   Check publisher's open access policy
ISSN 0818-9641
Publication date 2012-10
Sub-type Article (original research)
DOI 10.1038/icb.2012.24
Open Access Status File (Author Post-print)
Volume 90
Issue 9
Start page 889
End page 895
Total pages 7
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2013
Language eng
Formatted abstract
The distribution and function of the C-type lectin Mincle has not previously been investigated in human cells, although mouse models have demonstrated a non-redundant role for Mincle in the host response to fungal infections. This study identified an unusual pattern of reciprocal expression of Mincle on peripheral blood monocytes or neutrophils isolated from the same donor. Expression on monocytes was inversely correlated with phagocytosis and yeast killing, but was necessary for the induction of inflammatory cytokines in response to ex vivo Candida challenge. In contrast, Mincle expression on neutrophils was associated with phagocytic and candidacidal potential of those cells. Candida challenge upregulated Mincle expression but only in Mincle+ cells. These data highlight species-specific differences between the regulation of Mincle expression in mouse and man. Reciprocal expression of Mincle modified the candidacidal potential of monocytes or neutrophils, suggesting it may also polarize the type of host response to fungal infection
Keyword Candida infections
C Type Lectin
Dichotomous expression
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Dentistry Publications
Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 18 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 16 times in Scopus Article | Citations
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