Urinary biomarkers in obstructive nephropathy

Trnka, Peter, Ivanova, Larissa, Hiatt, Michael J. and Matsell, Douglas G. (2012) Urinary biomarkers in obstructive nephropathy. Clinical Journal of the American Society of Nephrology, 7 10: 1567-1575. doi:10.2215/CJN.09640911

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Author Trnka, Peter
Ivanova, Larissa
Hiatt, Michael J.
Matsell, Douglas G.
Title Urinary biomarkers in obstructive nephropathy
Journal name Clinical Journal of the American Society of Nephrology   Check publisher's open access policy
ISSN 1555-9041
Publication date 2012-10
Year available 2012
Sub-type Article (original research)
DOI 10.2215/CJN.09640911
Volume 7
Issue 10
Start page 1567
End page 1575
Total pages 9
Place of publication Washington, DC, United States
Publisher American Society of Nephrology
Collection year 2013
Language eng
Formatted abstract
Background and objectives: Obstructive nephropathy is a leading cause of CKD in children. The assessment of severity of renal impairment and the prediction of which children will progress to renal failure are, however, challenging.

Design, Setting, Participants, & Measurements:
This case-control study measured the urinary excretion of candidate biomarkers in 27 prevalent case-patients with posterior urethral valves (PUVs) and 20 age-matched controls, correlated their urinary concentration with GFR, and analyzed receiver-operating characteristic (ROC) curve and regression analyses to assess their performance as tests for low GFR.

Results: The median urinary protein-to-creatinine ratio was higher in children with PUV (45 g/mol; range, 5-361 g/mol) than in controls (7 g/mol; range, 3-43 g/mol) (P<0.01) and correlated inversely with renal function (r = -0.44; P<0.05). In whole urine, excretion of aquaporin-2 was significantly decreased, whereas that of TGFβ and L1 cell adhesion molecule (L1CAM) was significantly increased. Whole-urine TGFβ excretion correlated inversely with GFR (r = -0.53; P<0.05). As tests for low GFR, whole-urine TGFβ, L1CAM, and urinary proteinto-creatinine ratio performed best, with areas under the ROC curves of 0.788, 0.795, and 0.814, respectively. By linear regression analysis, whole-urine TGFβ, L1CAM, and urinary protein-to-creatinine ratio were associated with low GFR in the case-patients.

Conclusions: Candidate biomarkers of obstructive nephropathy can be readily measured in whole urine and in urine exosomes. In boys with PUV, these biomarkers correlate with GFR.
Keyword Obstructive nephropathy
Chronic kidney disease
Urinary excretion
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: August 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
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