Turning back the cardiac regenerative clock: lessons from the neonate

Mahmoud, Ahmed I. and Porrello, Enzo R. (2012) Turning back the cardiac regenerative clock: lessons from the neonate. Trends in Cardiovascular Medicine, 22 5: 128-133. doi:10.1016/j.tcm.2012.07.008

Author Mahmoud, Ahmed I.
Porrello, Enzo R.
Title Turning back the cardiac regenerative clock: lessons from the neonate
Journal name Trends in Cardiovascular Medicine   Check publisher's open access policy
ISSN 1050-1738
Publication date 2012-07
Sub-type Article (original research)
DOI 10.1016/j.tcm.2012.07.008
Volume 22
Issue 5
Start page 128
End page 133
Total pages 6
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Collection year 2013
Language eng
Abstract The adult mammalian heart has an extremely limited capacity for regeneration. As a consequence, ischemic heart disease remains the leading cause of death in the developed world, and the heart continues to be a major focal point for regenerative medicine. Understanding innate mechanisms of heart regeneration is important and may provide a blueprint for clinical translation. For example, urodele amphibians and teleost fish can mount an endogenous regenerative response following multiple forms of cardiac injury, and this regenerative response appears to be mediated through proliferation of pre-existing cardiomyocytes. How and why mammals have lost the capacity for heart regeneration since the divergence from teleost fish more than 450 million years ago has been a major unresolved question in the field. Recent studies in mice indicate that the mammalian heart possesses significant regenerative potential during embryonic and neonatal life, but this regenerative capacity is lost rapidly after birth. This review focuses on mechanisms of heart regeneration in neonatal mice, with a particular emphasis on similarities and differences with the zebrafish model. Recent advances in our understanding of the molecular mechanisms of postnatal heart maturation and regenerative arrest are also highlighted. The possibility of recapitulating ontogenetically and phylogenetically ancient mechanisms of cardiac regeneration in the adult human heart represents an exciting new frontier in cardiology.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Biomedical Sciences Publications
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