New and future developments of therapy for asthma in children

Sly, Peter D. and Jones, Carmen M. (2012). New and future developments of therapy for asthma in children. In Kai-Håkon Carlsen and Jorrit Gerritsen (Ed.), Paediatric Asthma (pp. 224-234) Lausanne, Switzerland: European Respiratory Society. doi:10.1183/1025448x.10018310

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Author Sly, Peter D.
Jones, Carmen M.
Title of chapter New and future developments of therapy for asthma in children
Title of book Paediatric Asthma
Place of Publication Lausanne, Switzerland
Publisher European Respiratory Society
Publication Year 2012
Sub-type Research book chapter (original research)
DOI 10.1183/1025448x.10018310
Series European respiratory monograh
ISBN 9781849840200
ISSN 2075-6674
Editor Kai-Håkon Carlsen
Jorrit Gerritsen
Volume number 56
Chapter number 19
Start page 224
End page 234
Total pages 11
Total chapters 19
Collection year 2013
Language eng
Abstract/Summary Treatment of childhood asthma has not changed substantially in recent decades, with no truly new drugs having been introduced since the turn of the last century. Mainstream therapy consists largely of inhaled corticosteroids in combination with β-agonists. Montelukast has a role in treating viral-induced wheeze in younger children and in preventing exercise-induced asthma. Review of the currently registered clinical trials for childhood asthma does not reveal any exciting new drug prospects. In recognition of the generally poor adherence with asthma therapy, a substantial research effort is underway to test strategies designed to improve asthma management with existing medications. Novel drugs with potential activity in asthma are currently being trialled in adults with asthma and some of these may eventually find their way into paediatric use. However, themost exciting advances in childhood asthma are likely to come from trials designed to prevent asthma. While several potential strategies can be identified from epidemiological studies, well conducted randomised clinical trials will be required to determine whether they are effective.
Keyword Asthma
Clinical trials
Complementary and alternative medicine
Drug development pipeline
Prevention of asthma
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online May 31, 2012.

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