A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol

Surakka, Ida, Whitfield, John B., Perola, Markus, Visscher, Peter M., Montgomery, Grant W., Falchi, Mario, Willemsen, Gonneke, de Geus, Eco J. C., Magnusson, Patrik K. E., Christensen, Kaare, Sorensen, Thorild I. A., Pietilainen, Kirsi H., Rantanen, Taina, Silander, Kaisa, Widen, Elisabeth, Muilu, Juhu, Rahman, Iffat, Liljedahl, Ulrika, Syvanen, Ann-Christine, Palotie, Aarno, Kaprio, Jaakko, Kyvik, Kirsten O., Pedersen, Nancy L., Boomsma, Dorret I., Spector, Tim, Martin, Nicolas G., Ripatti, Samuli and Peltonen, Leena (2012) A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol. Twin Research and Human Genetics, 15 6: 691-699. doi:10.1017/thg.2012.63


Author Surakka, Ida
Whitfield, John B.
Perola, Markus
Visscher, Peter M.
Montgomery, Grant W.
Falchi, Mario
Willemsen, Gonneke
de Geus, Eco J. C.
Magnusson, Patrik K. E.
Christensen, Kaare
Sorensen, Thorild I. A.
Pietilainen, Kirsi H.
Rantanen, Taina
Silander, Kaisa
Widen, Elisabeth
Muilu, Juhu
Rahman, Iffat
Liljedahl, Ulrika
Syvanen, Ann-Christine
Palotie, Aarno
Kaprio, Jaakko
Kyvik, Kirsten O.
Pedersen, Nancy L.
Boomsma, Dorret I.
Spector, Tim
Martin, Nicolas G.
Ripatti, Samuli
Peltonen, Leena
Title A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol
Journal name Twin Research and Human Genetics   Check publisher's open access policy
ISSN 1832-4274
1832-4274
Publication date 2012-10
Sub-type Article (original research)
DOI 10.1017/thg.2012.63
Open Access Status
Volume 15
Issue 6
Start page 691
End page 699
Total pages 9
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Collection year 2013
Language eng
Formatted abstract
Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene–environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, andmeasured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors (P =3.98×10−8). We followed up the association in further genotyped monozygotic twins (N =1,261), which showed a moderate association for the variant (P =0.200, same direction of an effect). In addition, we report a new association on the level of apolipoprotein A-II (P =4.03×10−8).
Keyword Twins
Association
Lipids
Apolipoproteins
Interaction
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 3 October 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2013 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 23 Nov 2012, 11:40:38 EST by Debra McMurtrie on behalf of Queensland Brain Institute