Phosphoinositides in neuroexocytosis and neuronal diseases

Wen, Peter J., Osborne, Shona L. and Meunier, Frederic A. (2012). Phosphoinositides in neuroexocytosis and neuronal diseases. In Marco Falasca and Peter K. Vogt (Ed.), Current topics in microbiology and immunology (pp. 87-98) Amsterdam, Netherlands: Springer. doi:10.1007/978-94-007-5025-8_4

Author Wen, Peter J.
Osborne, Shona L.
Meunier, Frederic A.
Title of chapter Phosphoinositides in neuroexocytosis and neuronal diseases
Title of book Current topics in microbiology and immunology
Place of Publication Amsterdam, Netherlands
Publisher Springer
Publication Year 2012
Sub-type Research book chapter (original research)
DOI 10.1007/978-94-007-5025-8_4
Open Access Status
Series Phosphoinositides and Disease
ISBN 9789400750241
ISSN 0070-217X
Editor Marco Falasca
Peter K. Vogt
Volume number 362
Chapter number 4
Start page 87
End page 98
Total pages 12
Total chapters 12
Collection year 2013
Language eng
Abstract/Summary Phosphoinositides (PIs) are a family of phospholipids derived from phosphatidylinositol (PtdIns), whose location, synthesis, and degradation depend on specific PI kinases and phosphatases. PIs have emerged as fundamental regulators of secretory processes, such as neurotransmitter release, hormone secretion, and histamine release in allergic responses. In neurons and neuroendocrine cells, regulated secretion requires the calcium-dependent fusion of transmitter-containing vesicles with the plasma membrane. The role played by PIs in exocytosis is best exemplified by the Ca2+-dependent binding of vesicular Synaptotagmin1 to the plasma membrane PtdIns(4,5)P2, and the recently demonstrated role of PtdIns(4,5)P2 in the mobilization of secretory vesicles to the plasma membrane. New evidence has also recently emerged of an alternative PI pathway that can control exocytosis positively (via PtdIn3P) or negatively (via PtdIns(3,5)P2). However, the positive or negative effectors for these pathways remain to be established. Reducing PtdIns(3,5)P2 potentiates neuroexocytosis but leads to neuronal degeneration and has been linked to certain forms of Charcot-Marie- Tooth disease and amyotrophic lateral sclerosis. The goal of this review is to describe the role of PIs in neuroexocytosis and explore the current hypotheses linking these effects to human diseases.
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Book Chapter
Collections: Queensland Brain Institute Publications
Official 2013 Collection
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Created: Wed, 21 Nov 2012, 13:53:23 EST by Debra McMurtrie on behalf of Queensland Brain Institute