Smoking and drug interactions

Lucas, Catherine and Martin, Jennifer (2013) Smoking and drug interactions. Australian Prescriber, 36 3: 102-104a.

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Author Lucas, Catherine
Martin, Jennifer
Title Smoking and drug interactions
Journal name Australian Prescriber   Check publisher's open access policy
ISSN 0312-8008
Publication date 2013-06
Year available 2013
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 36
Issue 3
Start page 102
End page 104a
Total pages 4
Place of publication Deakin, ACT, Australia
Publisher National Prescribing Service
Collection year 2014
Language eng
Formatted abstract
When patients enter hospital they may have to stop smoking abruptly if the hospital has a ‘no smoking’ policy. Abrupt smoking cessation can affect the metabolism of drugs.

Cigarette smoking induces the activity of human cytochromes P450 (CYP) 1A2 and 2B6. These enzymes metabolise several clinically important drugs, including clozapine, olanzapine and methadone.

Decreased CYP1A2 activity after smoking cessation increases the risk of adverse drug reactions, with reports of increased toxicity from clozapine and olanzapine. Predicting the required dose reduction of drugs metabolised by CYP1A2 after smoking
cessation is challenging. Therapeutic drug monitoring should be used when possible.

Nicotine replacement therapy does not influence CYP1A2 activity.
Keyword Clozapine
Cytochrome P450
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Medicine Publications
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Created: Mon, 19 Nov 2012, 13:21:12 EST by Dr Jennifer Martin on behalf of School of Medicine