PDF receptor signaling in Caenorhabditis elegans modulates locomotion and egg-laying

Meelkop, Ellen, Temmerman, Liesbet, Janssen, Tom, Suetens, Nick, Beets, Isabel, Van Rompay, Liesbeth, Shanmugam, Nilesh, Husson, Steven J. and Schoofs, Liliane (2012) PDF receptor signaling in Caenorhabditis elegans modulates locomotion and egg-laying. Molecular and Cellular Endocrinology, 361 1-2: 232-240. doi:10.1016/j.mce.2012.05.001


Author Meelkop, Ellen
Temmerman, Liesbet
Janssen, Tom
Suetens, Nick
Beets, Isabel
Van Rompay, Liesbeth
Shanmugam, Nilesh
Husson, Steven J.
Schoofs, Liliane
Title PDF receptor signaling in Caenorhabditis elegans modulates locomotion and egg-laying
Formatted title
PDF receptor signaling in Caenorhabditis elegans modulates locomotion and egg-laying
Journal name Molecular and Cellular Endocrinology   Check publisher's open access policy
ISSN 0303-7207
1872-8057
Publication date 2012-09-25
Sub-type Article (original research)
DOI 10.1016/j.mce.2012.05.001
Volume 361
Issue 1-2
Start page 232
End page 240
Total pages 9
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier Ireland
Collection year 2013
Language eng
Formatted abstract
In Caenorhabditis elegans, pdfr-1 encodes three receptors of the secretin receptor family. These G protein-coupled receptors are activated by three neuropeptides, pigment dispersing factors 1a, 1b and 2, which are encoded by pdf-1 and pdf-2. We isolated a PDF receptor loss-of-function allele (lst34) by means of a mutagenesis screen and show that the PDF signaling system is involved in locomotion and egg-laying. We demonstrate that the pdfr-1 mutant phenocopies the defective locomotor behavior of the pdf-1 mutant and that pdf-1 and pdf-2 behave antagonistically. All three PDF receptor splice variants are involved in the regulation of locomotor behavior. Cell specific rescue experiments show that this pdf mediated behavior is regulated by neurons rather than body wall muscles. We also show that egg-laying patterns of pdf-1 and pdf-2 mutants are affected, but not those of pdfr-1 mutants, pointing to a novel role for the PDF-system in the regulation of egg-laying.
Keyword Pigment dispersing factor
PDF
Caenorhabditis elegans
Locomotion
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Queensland Brain Institute Publications
 
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