Precious cargo: regulation of sex-specific germ cell development in mice

Bowles, Josephine and Koopman, Peter A. (2012) Precious cargo: regulation of sex-specific germ cell development in mice. Sexual Development, 7 1-3: 46-60. doi:10.1159/000342072


Author Bowles, Josephine
Koopman, Peter A.
Title Precious cargo: regulation of sex-specific germ cell development in mice
Journal name Sexual Development   Check publisher's open access policy
ISSN 1661-5425
1661-5433
Publication date 2012-08-31
Sub-type Article (original research)
DOI 10.1159/000342072
Volume 7
Issue 1-3
Start page 46
End page 60
Total pages 15
Place of publication Basel, Switzerland
Publisher S. Karger AG
Collection year 2013
Language eng
Formatted abstract
Although mammalian sex determination is normally specified genetically by an XX or XY chromosome complement, germ cells develop as sperm or oocytes in response to molecular cues provided by the gonadal somatic cells. In an ovary, germ cells enter meiosis during fetal life, thereby committing to oogenesis. In a testis, germ cells do not enter meiosis until after birth, at puberty. Recent findings indicate that, in mice, the sex-specific timing of entry into meiosis is governed by the balance between 2 secreted signalling molecules, retinoic acid (RA), which promotes entry into meiosis, and fibroblast growth factor 9 (FGF9), which counteracts RA. The combined action of these 2 molecular regulators provides a safety mechanism to guard against germ cell dysregulation that can lead to infertility or germ cell cancers.
Keyword Fibroblast growth factor 9
Germ cells
Meiosis
Retinoic acid
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online August 31, 2012

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 16 Nov 2012, 14:34:26 EST by Susan Allen on behalf of Institute for Molecular Bioscience