Therapeutic potential of cone snail venom peptides (conopeptides)

Vetter, Irina and Lewis, Richard J. (2012) Therapeutic potential of cone snail venom peptides (conopeptides). Current Topics in Medicinal Chemistry, 12 14: 1546-1552. doi:10.2174/156802612802652457

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Vetter, Irina
Lewis, Richard J.
Title Therapeutic potential of cone snail venom peptides (conopeptides)
Journal name Current Topics in Medicinal Chemistry   Check publisher's open access policy
ISSN 1568-0266
1873-4294
Publication date 2012-07
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2174/156802612802652457
Volume 12
Issue 14
Start page 1546
End page 1552
Total pages 7
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Collection year 2013
Language eng
Abstract Cone snails have evolved many 1000s of small, structurally stable venom peptides (conopeptides) for prey capture and defense. Whilst <0.1% have been pharmacologically characterised, those with known function typically target membrane proteins of therapeutic importance, including ion channels, transporters and GPCRs. Several conopeptides reduce pain in animals models, with one in clinical development (χ-conopeptide analogue Xen2174) and one marketed (ω- conotoxin MVIIA or Prialt) for the treatment of severe pain. In addition to their therapeutic potential, conopeptides have been valuable probes for studying the role of a number of key membrane proteins in normal and disease physiology.
Keyword Conopeptides
Ion channels
GPCR
Cone snails
Venom peptides
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
Institute for Molecular Bioscience - Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 27 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 27 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 15 Nov 2012, 16:08:49 EST by System User on behalf of Institute for Molecular Bioscience