Mineralocorticoid receptors mediate cardiac remodelling in morphine-dependent rats

Mesripour, Azadeh, Iyer, Abishek and Brown, Lindsay (2012) Mineralocorticoid receptors mediate cardiac remodelling in morphine-dependent rats. Basic and Clinical Pharmacology and Toxicology, 111 2: 75-80. doi:10.1111/j.1742-7843.2012.00860.x


Author Mesripour, Azadeh
Iyer, Abishek
Brown, Lindsay
Title Mineralocorticoid receptors mediate cardiac remodelling in morphine-dependent rats
Journal name Basic and Clinical Pharmacology and Toxicology   Check publisher's open access policy
ISSN 1742-7835
1742-7843
Publication date 2012-08
Sub-type Article (original research)
DOI 10.1111/j.1742-7843.2012.00860.x
Volume 111
Issue 2
Start page 75
End page 80
Total pages 6
Place of publication West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2013
Language eng
Abstract Acute morphine administration decreases cardiac responses to ischaemic injury. This project has determined whether induction of morphine dependence in rats by gradually increasing morphine doses for 21 days induces structural and functional changes in the cardiovascular system because of mineralocorticoid receptor activation, as morphine increases plasma corticosterone concentrations. Morphine-dependent rats showed ventricular hypertrophy, increased collagen deposition in the left ventricle together with an increased ventricular stiffness and increased plasma malondialdehyde concentrations without changes in systolic blood pressure or thoracic aortic responsiveness. These parameters were attenuated or normalised in morphine-dependent rats treated with spironolactone (50 mg/kg/day) from days 14–21. These results suggest that morphine dependence induces ventricular remodelling and increased oxidative stress that can be prevented by the mineralocorticoid receptor antagonist, spironolactone.
Keyword Heart-failure
Cardiovascular changes
Reperfusion injury
Opioid receptors
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Biomedical Sciences Publications
 
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