Altered spontaneous activity in anisometropic amblyopia subjects: revealed by resting-state fMRI

Lin, Xiaoming, Ding, Kun, Liu, Yong, Yan, Xiaohe, Song, Shaojie and Jiang, Tianzi (2012) Altered spontaneous activity in anisometropic amblyopia subjects: revealed by resting-state fMRI. PLoS One, 7 8: e43373.1-e43373.8. doi:10.1371/journal.pone.0043373

Author Lin, Xiaoming
Ding, Kun
Liu, Yong
Yan, Xiaohe
Song, Shaojie
Jiang, Tianzi
Title Altered spontaneous activity in anisometropic amblyopia subjects: revealed by resting-state fMRI
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2012-08
Sub-type Article (original research)
DOI 10.1371/journal.pone.0043373
Open Access Status DOI
Volume 7
Issue 8
Start page e43373.1
End page e43373.8
Total pages 8
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Collection year 2013
Language eng
Formatted abstract
Amblyopia, also known as lazy eye, usually occurs during early childhood and results in poor or blurred vision. Recent neuroimaging studies have found cortical structural/functional abnormalities in amblyopia. However, until now, it was still not known whether the spontaneous activity of the brain changes in amblyopia subjects. In the present study, regional homogeneity (ReHo), a measure of the homogeneity of functional magnetic resonance imaging signals, was used for the first time to investigate changes in resting-state local spontaneous brain activity in individuals with anisometropic amblyopia. Compared with age- and gender-matched subjects with normal vision, the anisometropic amblyopia subjects showed decreased ReHo of spontaneous brain activity in the right precuneus, the left medial prefrontal cortex, the left inferior frontal gyrus, and the left cerebellum, and increased ReHo of spontaneous brain activity was found in the bilateral conjunction area of the postcentral and precentral gyri, the left paracentral lobule, the left superior temporal gyrus, the left fusiform gyrus, the conjunction area of the right insula, putamen and the right middle occipital gyrus. The observed decreases in ReHo may reflect decreased visuo-motor processing ability, and the increases in ReHo in the somatosensory cortices, the motor areas and the auditory area may indicate compensatory plasticity in amblyopia
Keyword Transcranial Magnetic Stimulation
Diffusion Tensor Tractography
Positron-Emission Tomography
Regional Homogeneity Changes
Lateral Geniculate Nucleus
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article no. e43373

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2013 Collection
Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
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Created: Thu, 15 Nov 2012, 15:56:58 EST by System User on behalf of Queensland Brain Institute