Circular proteins from plants and fungi

Goransson, Ulf, Burman, Robert, Gunasekera, Sunithi, Stromstedt, Adam A. and Rosengren, K. Johan (2012) Circular proteins from plants and fungi. Journal of Biological Chemistry, 287 32: 27001-27006. doi:10.1074/jbc.R111.300129

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Author Goransson, Ulf
Burman, Robert
Gunasekera, Sunithi
Stromstedt, Adam A.
Rosengren, K. Johan
Title Circular proteins from plants and fungi
Journal name Journal of Biological Chemistry   Check publisher's open access policy
ISSN 0021-9258
Publication date 2012-08
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1074/jbc.R111.300129
Open Access Status File (Publisher version)
Volume 287
Issue 32
Start page 27001
End page 27006
Total pages 6
Place of publication Bethesda, MD United States
Publisher American Society for Biochemistry and Molecular Biology
Collection year 2012
Language eng
Formatted abstract
Circular proteins, defined as head-to-tail cyclized polypeptides originating from ribosomal synthesis, represent a novel class of natural products attracting increasing interest. From a scientific point of view, these compounds raise questions of where and why they occur in nature and how they are formed. From a rational point of view, these proteins and their structural concept may be exploited for crop protection and novel pharmaceuticals. Here, we review the current knowledge of three protein families: cyclotides and circular sunflower trypsin inhibitors from the kingdom of plants and the Amanita toxins from fungi. A particular emphasis is placed on their biological origin, structure, and activity. In addition, the opportunity for discovery of novel circular proteins and recent insights into their mechanism of action are discussed.
Keyword Cyclotide Kalata B1
Trypsin-Inhibitor Sfti-1
Cyclic Cystine Knot
Oldenlandia affinis
Cycloviolacin O2
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
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