Review of neonatal alloimmune thrombocytopenia

Risson, David C., Davies, Mark W. and Williams, Bronwyn A. (2012) Review of neonatal alloimmune thrombocytopenia. Journal of Paediatrics and Child Health, 48 9: 816-822. doi:10.1111/j.1440-1754.2012.02528.x


Author Risson, David C.
Davies, Mark W.
Williams, Bronwyn A.
Title Review of neonatal alloimmune thrombocytopenia
Journal name Journal of Paediatrics and Child Health   Check publisher's open access policy
ISSN 1034-4810
1440-1754
Publication date 2012-09
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1440-1754.2012.02528.x
Volume 48
Issue 9
Start page 816
End page 822
Total pages 7
Place of publication West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2013
Language eng
Abstract Neonatal alloimmune thrombocytopenia (NAIT), with an incidence of one in 1000 live births, is the most common cause of severe thrombocytopenia and intra-cerebral haemorrhage in term neonates. NAIT results from trans-placental passage of maternal antibodies against a paternally derived fetal platelet alloantigen. Clinical presentation varies from unexpected thrombocytopenia on a blood film in a well newborn to intracranial haemorrhage (ICH). In contrast to haemolytic disease of the newborn, NAIT can present in a first pregnancy, and subsequent pregnancies are usually more severely affected. The role of antenatal screening for maternal alloantibodies instead of fetal blood sampling to identify at-risk fetuses remains uncertain, but there is a trend towards less invasive maternally directed treatment for at-risk pregnancies. Neonatal management is aimed at preventing or limiting thrombocytopenic bleeding with transfusion of antigen-matched platelets.
Keyword Human platelet antigens
Neonatal alloimmune thrombocytopenia
Neonatal thrombocytopenia
Human platelet antigens
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
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