Development of a quantitative multivariable radiographic method to evaluate anatomic changes associated with laminitis in the forefeet of donkeys

Collins, Simon N., Dyson, Sue J., Murray, Rachel C., Newton, J. Richard, Burden, Faith and Trawford, Andrew F. (2012) Development of a quantitative multivariable radiographic method to evaluate anatomic changes associated with laminitis in the forefeet of donkeys. American Journal of Veterinary Research, 73 8: 1207-1218. doi:10.2460/ajvr.73.8.1207


Author Collins, Simon N.
Dyson, Sue J.
Murray, Rachel C.
Newton, J. Richard
Burden, Faith
Trawford, Andrew F.
Total Author Count Override 6
Title Development of a quantitative multivariable radiographic method to evaluate anatomic changes associated with laminitis in the forefeet of donkeys
Journal name American Journal of Veterinary Research   Check publisher's open access policy
ISSN 0002-9645
1943-5681
Publication date 2012-08
Sub-type Article (original research)
DOI 10.2460/ajvr.73.8.1207
Volume 73
Issue 8
Start page 1207
End page 1218
Total pages 12
Place of publication Schaumburg, IL United States
Publisher American Veterinary Medical Association
Collection year 2013
Language eng
Formatted abstract
Objective—To establish and validate an objective method of radiographic diagnosis of anatomic changes in laminitic forefeet of donkeys on the basis of data from a comprehensive series of radiographic measurements.
Animals—85 donkeys with and 85 without forelimb laminitis for baseline data determination; a cohort of 44 donkeys with and 18 without forelimb laminitis was used for validation analyses.
Procedures—For each donkey, lateromedial radiographic views of 1 weight-bearing forelimb were obtained; images from 11 laminitic and 2 nonlaminitic donkeys were excluded (motion artifact) from baseline data determination. Data from an a priori selection of 19 measurements of anatomic features of laminitic and nonlaminitic donkey feet were analyzed by use of a novel application of multivariate statistical techniques. The resultant diagnostic models were validated in a blinded manner with data from the separate cohort of laminitic and nonlaminitic donkeys.
Results—Data were modeled, and robust statistical rules were established for the diagnosis of anatomic changes within laminitic donkey forefeet. Component 1 scores ≤ –3.5 were indicative of extreme anatomic change, and scores from –2.0 to 0.0 denoted modest change. Nonlaminitic donkeys with a score from 0.5 to 1.0 should be considered as at risk for laminitis.
Conclusions and Clinical Relevance—Results indicated that the radiographic procedures evaluated can be used for the identification, assessment, and monitoring of anatomic changes associated with laminitis. Screening assessments by use of this method may enable early detection of mild anatomic change and identification of at-risk donkeys.
Keyword Equine Laminitis
Distal Phalanx
Horses
Prognosis
Rotation
Disease
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Veterinary Science Publications
 
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