Improvements in Cystic Fibrosis Lung Disease and Airway Inflammation Associated with Etanercept Therapy for Rheumatoid Arthritis: A Case Report

Visser, S., Martin, M. and Serisier, D. J. (2012) Improvements in Cystic Fibrosis Lung Disease and Airway Inflammation Associated with Etanercept Therapy for Rheumatoid Arthritis: A Case Report. Lung, 190 5: 579-581.


Author Visser, S.
Martin, M.
Serisier, D. J.
Title Improvements in Cystic Fibrosis Lung Disease and Airway Inflammation Associated with Etanercept Therapy for Rheumatoid Arthritis: A Case Report
Journal name Lung   Check publisher's open access policy
ISSN 0341-2040
Publication date 2012-10
Sub-type Article (original research)
DOI 10.1007/s00408-012-9393-9
Volume 190
Issue 5
Start page 579
End page 581
Total pages 3
Place of publication Secaucus, NJ, U.S.A.
Publisher Springer New York LLC
Collection year 2013
Language eng
Abstract Cystic fibrosis (CF) lung pathology is characterized by excessive neutrophilic inflammation and high tumor necrosis factor-alpha (TNF-α) levels. A cornerstone of CF management is reduction of the inflammatory burden in the lung. We present the case of a 19-year-old CF patient who demonstrated significant clinical improvement in her lung disease associated with a reduction in sputum percent neutrophils, following commencement of etanercept (TNF-α antagonist) for rheumatoid arthritis. She has not had any infectious complications or other significant adverse effects during 2 years of treatment. It may be time to reconsider TNF-α antagonists as potential anti-inflammatory agents for CF lung disease.
Keyword Cystic fibrosis
Etanercept
TNF-alpha antagonist
Lung function
Pulmonary
Exacerbation
Sputum percent neutrophils
Antagonists
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
 
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