Partitioning of persistent organic pollutants (POPs) between human serum and breast milk: a literature review

Mannetje, Andrea 't, Coakley, Jonathan, Mueller, Jochen F., Harden, Fiona, Toms, Leisa-Maree and Douwes, Jeroen (2012) Partitioning of persistent organic pollutants (POPs) between human serum and breast milk: a literature review. Chemosphere, 89 8: 911-918. doi:10.1016/j.chemosphere.2012.06.049


Author Mannetje, Andrea 't
Coakley, Jonathan
Mueller, Jochen F.
Harden, Fiona
Toms, Leisa-Maree
Douwes, Jeroen
Title Partitioning of persistent organic pollutants (POPs) between human serum and breast milk: a literature review
Journal name Chemosphere   Check publisher's open access policy
ISSN 0045-6535
1879-1298
Publication date 2012-11
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.chemosphere.2012.06.049
Open Access Status
Volume 89
Issue 8
Start page 911
End page 918
Total pages 8
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon
Collection year 2013
Language eng
Abstract The literature was reviewed to assess the relationship between the lipid adjusted concentration in human serum and breast milk (expressed as the serum/milk ratio) of a broad range of POPs in paired samples. Thirteen studies were identified, including seven studies that reported serum/milk ratios for polychlorinated dibenzo-dioxins and -furans (PCDD/Fs), ten for polychlorinated biphenyls (PCBs), five for polybrominated diphenyl ethers (PBDEs), and five for organochlorine pesticides (OCPs). Mean serum/milk ratios ranged between 0.7 and 25 depending on the compound and congener. For PCDD/Fs, PCBs and PBDEs, a clear trend of increasing mean serum/milk ratio by increasing molar volume, hydrophobicity and number of halogen substitutes was observed. The mean serum/milk ratios reported by the 13 studies summarized here will aid comparison between human POPs exposure studies using either serum or milk samples. More studies are needed to allow a valid comparison between data obtained from analysis of breast milk and serum samples for a broader range of POPs. Furthermore such studies may shed light on compound specific factors as well as other determinants that may affect the partitioning and partition kinetics of POPs between serum and breast milk.
Keyword PCDD/Fs
PCBs
PBDEs
Organochlorine pesticides
Human serum
Breast milk
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online: 4 August 2012.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
National Research Centre for Environmental Toxicology Publications
 
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